ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience1998
Expression of the mitotic motor protein Eg5 in postmitotic neurons: implications for neuronal development.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
36 citing papers in PubMed, 92 citations in OpenAlex.
- Intellectual disability-causing mutations in KIF11 impair microtubule dynamics and dendritic arborization.Nature communications · 2026Article
- Mitotic Functions and Characters of KIF11 in Cancers.Biomolecules · 2024Review
- Article
- IncreasediScience · 2022Article
- Phosphorylation of XPD drives its mitotic role independently of its DNA repair and transcription functions.Science advances · 2022Article
- KIFC1 Regulates the Trajectory of Neuronal Migration.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Mini-review: Microtubule sliding in neurons.Neuroscience letters · 2021Review
- Unconventional Roles of Cytoskeletal Mitotic Machinery in Neurodevelopment.Trends in cell biology · 2019Review
- Mitotic Motor KIFC1 Is an Organizer of Microtubules in the Axon.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Cancer drug therapy and stochastic modeling of "nano-motors".International journal of nanomedicine · 2018Article
- KIF11 is required for proliferation and self-renewal of docetaxel resistant triple negative breast cancer cells.Oncotarget · 2017Article
- Microtubules and Growth Cones: Motors Drive the Turn.Trends in neurosciences · 2016Review
- Inhibition of the Motor Protein Eg5/Kinesin-5 in Amyloid β-Mediated Impairment of Hippocampal Long-Term Potentiation and Dendritic Spine Loss.Molecular pharmacology · 2016Article
- Tau excess impairs mitosis and kinesin-5 function, leading to aneuploidy and cell death.Disease models & mechanisms · 2016Article
- Microtubule-binding protein doublecortin-like kinase 1 (DCLK1) guides kinesin-3-mediated cargo transport to dendrites.The EMBO journal · 2016Article
- The mitotic spindle: linking teratogenic effects of Zika virus with human genetics?Molecular cytogenetics · 2016Article
- TPX2 regulates neuronal morphology through kinesin-5 interaction.Cytoskeleton (Hoboken, N.J.) · 2015Article
- Inhibition of kinesin-5 improves regeneration of injured axons by a novel microtubule-based mechanism.Neural regeneration research · 2015Review
- Ciliobrevins as tools for studying dynein motor function.Frontiers in cellular neuroscience · 2015Review
- Effects of kinesin-5 inhibition on dendritic architecture and microtubule organization.Molecular biology of the cell · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It is well established that the microtubules of the mitotic spindle are organized by a variety of motor proteins, and it appears that the same motors or closely related variants organize microtubules in the postmitotic neuron. Specifically, cytoplasmic dynein and the kinesin-related motor known as CHO1/MKLP1 are used within the mitotic spindle, and recent studies suggest that they are also essential for the establishment of the axonal and dendritic microtubule arrays of the neuron. Other motors are required to tightly regulate microtubule behaviors in the mitotic spindle, and it is attractive to speculate that these motors might also help to regulate microtubule behaviors in the neuron. Here we show that a homolog of the mitotic kinesin-related motor known as Eg5 continues to be expressed in rodent neurons well after their terminal mitotic division. In neurons, Eg5 is directly associated with the microtubule array and is enriched within the distal regions of developing processes. This distal enrichment is transient, and typically lost after a process has been clearly defined as an axon or a dendrite. Strong expression can resume later in development, and if so, the protein concentrates within newly forming sprouts at the distal tips of dendrites. We suggest that Eg5 generates forces that help to regulate microtubule behaviors within the distal tips of developing axons and dendrites.
Indexed as
Identifiers
9742151PMC6793023W2121307506What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.