ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience1998
A role for cyclin-dependent kinase(s) in the modulation of fast anterograde axonal transport: effects defined by olomoucine and the APC tumor suppressor protein.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed.
- New insights into mitochondrial segregation from the Doubly Uniparental Inheritance system in bivalves.BMC biology · 2025Article
- Comparison among Neuroblastoma Stages Suggests the Involvement of Mitochondria in Tumor Progression.Biomedicines · 2023Article
- Tau: A Signaling Hub Protein.Frontiers in molecular neuroscience · 2021Article
- Regulation of motor proteins, axonal transport deficits and adult-onset neurodegenerative diseases.Neurobiology of disease · 2017Review
- Biochemical analysis of axon-specific phosphorylation events using isolated squid axoplasms.Methods in cell biology · 2016Article
- Axonal transport defects in Alzheimer's disease.Molecular neurobiology · 2015Review
- Trafficking of ThermoTRP Channels.Membranes · 2014Review
- The sphingolipid psychosine inhibits fast axonal transport in Krabbe disease by activation of GSK3β and deregulation of molecular motors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Mitochondrial trafficking in neurons.Cold Spring Harbor perspectives in biology · 2013Review
- Axonal transport deficits and neurodegenerative diseases.Nature reviews. Neuroscience · 2013Review
- Cyclin-dependent kinase 5 controls TRPV1 membrane trafficking and the heat sensitivity of nociceptors through KIF13B.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- The kinesin-3 family motor KLP-4 regulates anterograde trafficking of GLR-1 glutamate receptors in the ventral nerve cord of Caenorhabditis elegans.Molecular biology of the cell · 2012Article
- At the Fulcrum in Health and Disease: Cdk5 and the Balancing Acts of Neuronal Structure and Physiology.Brain disorders & therapy · 2012Article
- Cyclin-dependent kinase 5 regulates the polarized trafficking of neuropeptide-containing dense-core vesicles in Caenorhabditis elegans motor neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- The axonal transport of mitochondria.Journal of cell science · 2012Review
- Mitochondrial configurations in peripheral nerve suggest differential ATP production.Journal of structural biology · 2011Article
- Article
- Mitochondrial membrane potential in axons increases with local nerve growth factor or semaphorin signaling.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2008Article
- CDK-5 regulates the abundance of GLR-1 glutamate receptors in the ventral cord of Caenorhabditis elegans.Molecular biology of the cell · 2007Article
- Spatiotemporal regulation of ATP and Ca2+ dynamics in vertebrate rod and cone ribbon synapses.Molecular vision · 2007Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Proteins that interact with both cytoskeletal and membrane components are candidates to modulate membrane trafficking. The tumor suppressor proteins neurofibromin (NF1) and adenomatous polyposis coli (APC) both bind to microtubules and interact with membrane-associated proteins. The effects of recombinant NF1 and APC fragments on vesicle motility were evaluated by measuring fast axonal transport along microtubules in axoplasm from squid giant axons. APC4 (amino acids 1034-2844) reduced only anterograde movements, whereas APC2 (aa 1034-2130) or APC3 (aa 2130-2844) reduced both anterograde and retrograde transport. NF1 had no effect on organelle movement in either direction. Because APC contains multiple cyclin-dependent kinase (CDK) consensus phosphorylation motifs, the kinase inhibitor olomoucine was examined. At concentrations in which olomoucine is specific for cyclin-dependent kinases (5 microM), it reduced only anterograde transport, whereas anterograde and retrograde movement were both affected at concentrations at which other kinases are inhibited as well (50 microM). Both anterograde and retrograde transport also were inhibited by histone H1 and KSPXK peptides, substrates for proline-directed kinases, including CDKs. Our data suggest that CDK-like axonal kinases modulate fast anterograde transport and that other axonal kinases may be involved in modulating retrograde transport. The specific effect of APC4 on anterograde transport suggests a model in which the binding of APC to microtubules may limit the activity of axonal CDK kinase or kinases in restricted domains, thereby affecting organelle transport.
Indexed as
Identifiers
9742142PMC6793030What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.