ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience1998
Tyrosine hydroxylase expression in primary cultures of olfactory bulb: role of L-type calcium channels.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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Who cites it
21 citing papers in PubMed, 50 citations in OpenAlex.
- Brief sensory deprivation triggers plasticity of dopamine-synthesising enzyme expression in genetically labelled olfactory bulb dopaminergic neurons.The European journal of neuroscience · 2022Article
- Brief Sensory Deprivation Triggers Cell Type-Specific Structural and Functional Plasticity in Olfactory Bulb Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Illuminating and Sniffing Out the Neuromodulatory Roles of Dopamine in the Retina and Olfactory Bulb.Frontiers in cellular neuroscience · 2020Review
- Odorant Sensory Input Modulates DNA Secondary Structure Formation and Heterogeneous Ribonucleoprotein Recruitment on the Tyrosine Hydroxylase and Glutamic Acid Decarboxylase 1 Promoters in the Olfactory Bulb.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Quantification of dopaminergic neuron differentiation and neurotoxicity via a genetic reporter.Scientific reports · 2016Article
- A distinct subtype of dopaminergic interneuron displays inverted structural plasticity at the axon initial segment.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Epigenetic control of neurotransmitter expression in olfactory bulb interneurons.International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience · 2013Review
- Histone deacetylase inhibitors de-repress tyrosine hydroxylase expression in the olfactory bulb and rostral migratory stream.Biochemical and biophysical research communications · 2010Article
- gamma-Aminobutyric acid-mediated regulation of the activity-dependent olfactory bulb dopaminergic phenotype.Journal of neuroscience research · 2009Article
- Dopamine systems in the forebrain.Advances in experimental medicine and biology · 2009Review
- Activity-dependent regulation of tyrosine hydroxylase expression in the enteric nervous system.The Journal of physiology · 2008Article
- Interferon-gamma-induced inhibition of neuronal vesicular stomatitis virus infection is STAT1 dependent.Journal of neurovirology · 2004Article
- Cortical and striatal expression of tyrosine hydroxylase mRNA in neonatal and adult mice.Cellular and molecular neurobiology · 2003Article
- Interactions with PDZ proteins are required for L-type calcium channels to activate cAMP response element-binding protein-dependent gene expression.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2003Article
- Regulation of tyrosine hydroxylase expression in tottering mouse Purkinje cells.Neurotoxicity research · 2003Article
- Physiological patterns of electrical stimulation can induce neuronal gene expression by activating N-type calcium channels.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2001Article
- Defect of tyrosine hydroxylase-immunoreactive neurons in the brains of mice lacking the transcription factor Pax6.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2000Article
- Sustained activation of hippocampal Lp-type voltage-gated calcium channels by tetanic stimulation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2000Article
- Critical dependence of cAMP response element-binding protein phosphorylation on L-type calcium channels supports a selective response to EPSPs in preference to action potentials.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2000Article
- Odor-induced, activity-dependent transneuronal gene induction in vitro: mediation by NMDA receptors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1999Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Sensory activity mediates regulation of tyrosine hydroxylase (TH), the first enzyme in the dopamine biosynthetic pathway, in the rodent olfactory bulb. The current studies established for the first time primary cultures of neonatal mouse olfactory bulb expressing TH and tested whether L-type calcium channels mediate the activity-dependent regulation of the dopamine phenotype. After 1 d in vitro (DIV), a small population of TH-immunostained neurons that lacked extensive processes could be demonstrated. After an additional 2 DIV in serum-free medium, the number of TH neurons had doubled, and they exhibited long interdigitating processes. Membrane depolarization for 48 hr with 50 mM KCl produced a further 2.4-fold increase in the number of TH-immunoreactive neurons compared with control cultures. Increased TH neuron number required at least 36 hr of exposure to KCl. Forskolin, which increases intracellular cAMP levels, induced a 1.5- to 1.6-fold increase in the number of TH-immunostained neurons. Combined treatment with KCl and forskolin was not additive. Nifedipine, an L-type calcium channel blocker, completely prevented the depolarization-mediated increase in TH expression but did not block the response to forskolin. Treatment with Bay K8644, an L-type calcium channel agonist, also significantly increased the number of TH-expressing neurons. Depolarization also induced alterations in neuritic outgrowth, resulting in a stellate versus an elongate morphology that, in contrast, was not prevented by nifedipine. These results are the first demonstration that in vitro, as in vivo, depolarization increases TH expression in olfactory bulb and that L-type calcium channels mediate this activity-dependent regulation of the dopamine phenotype.
Indexed as
Identifiers
9742135PMC6793028W2139549857What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.