ArticleEndocrine1998
Expression of ovine insulin-like growth factor-1 (IGF-1) stimulates alveolar bud development in mammary glands of transgenic mice.
Article in Endocrine, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 52 citations in OpenAlex.
- The Insulin-like Growth Factor Signaling Pathway in Breast Cancer: An Elusive Therapeutic Target.Life (Basel, Switzerland) · 2022Review
- The Multi-Faced Role of PAPP-A in Post-Partum Breast Cancer: IGF-Signaling is Only the Beginning.Journal of mammary gland biology and neoplasia · 2020Review
- Crosstalk between STAT5 activation and PI3K/AKT functions in normal and transformed mammary epithelial cells.Molecular and cellular endocrinology · 2017Review
- Stat5 regulates the phosphatidylinositol 3-kinase/Akt1 pathway during mammary gland development and tumorigenesis.Molecular and cellular biology · 2014Article
- Transgenic insulin-like growth factor-1 stimulates activation of COX-2 signaling in mammary glands.Molecular carcinogenesis · 2012Article
- Developmental stage determines estrogen receptor alpha expression and non-genomic mechanisms that control IGF-1 signaling and mammary proliferation in mice.The Journal of clinical investigation · 2012Article
- Alcohol exposure in utero leads to enhanced prepubertal mammary development and alterations in mammary IGF and estradiol systems.Hormones & cancer · 2011Article
- Elevated circulating IGF-I promotes mammary gland development and proliferation.Endocrinology · 2010Article
- Growth hormone and insulin-like growth factor-I in the transition from normal mammary development to preneoplastic mammary lesions.Endocrine reviews · 2009Review
- The impact of transgenic IGF-IR overexpression on mammary development and tumorigenesis.Journal of mammary gland biology and neoplasia · 2008Review
- Role of insulin-like growth factor binding proteins in mammary gland development.Journal of mammary gland biology and neoplasia · 2008Review
- Paracrine overexpression of insulin-like growth factor-1 enhances mammary tumorigenesis in vivo.The American journal of pathology · 2008Article
- Mammary specific transgenic over-expression of insulin-like growth factor-I (IGF-I) increases pig milk IGF-I and IGF binding proteins, with no effect on milk composition or yield.Transgenic research · 2005Article
- PTEN overexpression suppresses proliferation and differentiation and enhances apoptosis of the mouse mammary epithelium.The Journal of clinical investigation · 2002Article
- Real-time detection of insulin-like growth factor-1 stimulation of the MAC-T bovine mammary epithelial cell line.Endocrine · 2000Article
- The insulin-like growth factors (IGFs) and IGF binding proteins in postnatal development of murine mammary glands.Journal of mammary gland biology and neoplasia · 2000Review
- Local IGF-I axis in peripubertal ruminant mammary development.Journal of mammary gland biology and neoplasia · 2000Review
- IGF and insulin action in the mammary gland: lessons from transgenic and knockout models.Journal of mammary gland biology and neoplasia · 2000Review
- Stable production of human insulin-like growth factor 1 (IGF-1) in the milk of hemi- and homozygous transgenic rabbits over several generations.Transgenic research · 1998Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To determine whether murine mammary growth is modulated by local insulin-like growth factor-1 (IGF-1) production, expression of recombinant IGF-1 was directed to the mammary glands of transgenic mice using an ovine prepro IGF-1 cDNA under control of the mouse mammary tumor virus-long terminal repeat (MMTV-LTR) promoter. Bioactivity of recombinant IGF-1 in transgenic mouse milk extracts was demonstrated by a concentration-dependent increase in [3H]thymidine incorporation in clonal bovine mammary epithelial cells (MAC-T) compared with control mouse milk extracts; moreover, addition of excess recombinant human insulin-like growth factor binding protein-3 (rhlGFBP-3) abolished the increase in [3H]thymidine incorporation attributed to recombinant IGF-1 in transgenic mouse milk. Recombinant IGF-1 was produced in mammary tissue of virgin and pregnant transgenic mice, and secreted into milk of lactating mice. However, recombinant IGF-1 was not detected in serum from transgenic mice; and ligand blot analysis of serum insulin-like growth factor binding proteins (IGFBPs) indicated no differences owing to transgene presence. In peripubertal virgin mice at 49 d of age, the frequency of appearance of mammary alveolar buds was significantly higher in MMTV-IGF-1 than in CD-1 mice, and was unaffected by ovariectomy or estradiol treatment. In conclusion, mammary synthesis of recombinant IGF-1 enhances the rate of development of alveolar buds in mammary glands of virgin transgenic mice.
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