ArticleJournal of neurobiology1998
neuroD induces photoreceptor cell overproduction in vivo and de novo generation in vitro.
Article in Journal of neurobiology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
42 citing papers in PubMed, 108 citations in OpenAlex.
- Disease-causing mutations in genes encoding transcription factors critical for photoreceptor development.Frontiers in molecular neuroscience · 2023Review
- Hagfish to Illuminate the Developmental and Evolutionary Origins of the Vertebrate Retina.Frontiers in cell and developmental biology · 2022Review
- Direct conversion of adult human retinal pigmented epithelium cells to neurons with photoreceptor properties.Experimental biology and medicine (Maywood, N.J.) · 2021Article
- Cis-regulatory analysis of Onecut1 expression in fate-restricted retinal progenitor cells.Neural development · 2020Article
- Retinoid acid and taurine promote NeuroD1-induced differentiation of induced pluripotent stem cells into retinal ganglion cells.Molecular and cellular biochemistry · 2018Article
- The Effect of Traditional Chinese Medicine on Neural Stem Cell Proliferation and Differentiation.Aging and disease · 2017Review
- miR Cluster 143/145 Directly Targets Nrl and Regulates Rod Photoreceptor Development.Molecular neurobiology · 2017Article
- Photoreceptor-like cells from reprogramming cultured mammalian RPE cells.Molecular vision · 2013Article
- Production of high-titer RCAS retrovirus.Methods in molecular biology (Clifton, N.J.) · 2012Article
- Using the Tg(nrd:egfp)/albino zebrafish line to characterize in vivo expression of neurod.PloS one · 2012Article
- Chick retinal pigment epithelium transdifferentiation assay for proneural activities.Methods in molecular biology (Clifton, N.J.) · 2012Article
- Cytoskeleton proteins previously considered exclusive to ganglion cells are transiently expressed by all retinal neuronal precursors.BMC developmental biology · 2011Article
- Generating retinal neurons by reprogramming retinal pigment epithelial cells.Expert opinion on biological therapy · 2010Review
- Neurogenin1 effectively reprograms cultured chick retinal pigment epithelial cells to differentiate toward photoreceptors.The Journal of comparative neurology · 2010Article
- Using neurogenin to reprogram chick RPE to produce photoreceptor-like neurons.Investigative ophthalmology & visual science · 2010Article
- Pro-photoreceptor activity of chick neurogenin1.Investigative ophthalmology & visual science · 2009Article
- Reprogramming retinal pigment epithelium to differentiate toward retinal neurons with Sox2.Stem cells (Dayton, Ohio) · 2009Article
- Neurogenin3 promotes early retinal neurogenesis.Molecular and cellular neurosciences · 2009Article
- Thyroid hormone components are expressed in three sequential waves during development of the chick retina.BMC developmental biology · 2008Article
- Reprogramming progeny cells of embryonic RPE to produce photoreceptors: development of advanced photoreceptor traits under the induction of neuroD.Investigative ophthalmology & visual science · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The molecular mechanisms underlying the generation of the various types of cells in the vertebrate retina are largely unknown. We investigated the possibility that genes belonging to the basic helix-loop-helix (bHLH) family of transcriptional factors participate in cell-type specification during retinal neurogenesis. Chick neuroD was isolated from an embryonic cDNA library and its deduced amino acid sequence showed 75% identity with mouse neuroD. In situ hybridization showed that neuroD was expressed in cells located at the outer portion of the developing retinal neuroepithelium, the location where prospective photoreceptors reside. Misexpression of neuroD in retinal neuroepithelium through replication-competent, transformation-deficient retroviruses produced a retina with three, instead of two, layers of photoreceptor cells; the number of cells that express visinin, a marker for cone photoreceptors, increased over 50% compared to control embryos misexpressing the green fluorescent protein. No significant changes were observed in the number of other retinal neurons, including those that express RA4 (ganglion cells), pax6 (ganglion cells and amacrine cells), and chx10 (bipolar cells). Retroviral-driven misexpression of neuroD in monolayer cultures of retinal pigment epithelium yielded de novo production of photoreceptor cells with no other types of retinal neurons detected. We propose that neuroD is important for photoreceptor cell production in the vertebrate retina.
Indexed as
Identifiers
9740021PMC1764458W2092570467What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.