ArticleProceedings of the National Academy of Sciences of the United States of America1998
Active summation of excitatory postsynaptic potentials in hippocampal CA3 pyramidal neurons.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 83 citations in OpenAlex.
- In Vitro Patch-Clamp.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Strictly regulated agonist-dependent activation of AMPA-R is the key characteristic of TAK-653 for robust synaptic responses and cognitive improvement.Scientific reports · 2021Article
- Heterosynaptic Plasticity Determines the Set Point for Cortical Excitatory-Inhibitory Balance.Neuron · 2020Article
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- Effects of location and extent of spine clustering on synaptic integration in striatal medium spiny neurons-a computational study.Medical & biological engineering & computing · 2018Article
- Dendritic potassium channel dysfunction may contribute to dendrite degeneration in spinocerebellar ataxia type 1.PloS one · 2018Article
- The Endogenous Stress Hormone CRH Modulates Excitatory Transmission and Network Physiology in Hippocampus.Cerebral cortex (New York, N.Y. : 1991) · 2017Article
- The Shaping of Two Distinct Dendritic Spikes by A-Type Voltage-Gated K(+) Channels.Frontiers in cellular neuroscience · 2015Article
- Recurrent synapses and circuits in the CA3 region of the hippocampus: an associative network.Frontiers in cellular neuroscience · 2014Review
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- Saikosaponin a Enhances Transient Inactivating Potassium Current in Rat Hippocampal CA1 Neurons.Evidence-based complementary and alternative medicine : eCAM · 2013Article
- In vivo voltage-dependent influences on summation of synaptic potentials in neurons of the lateral nucleus of the amygdala.Neuroscience · 2012Article
- Active dendrites support efficient initiation of dendritic spikes in hippocampal CA3 pyramidal neurons.Nature neuroscience · 2012Article
- Article
- Non-additive coupling enables propagation of synchronous spiking activity in purely random networks.PLoS computational biology · 2012Article
- Passive and active shaping of unitary responses from associational/commissural and perforant path synapses in hippocampal CA3 pyramidal cells.Journal of computational neuroscience · 2011Article
- A neurally efficient implementation of sensory population decoding.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Asymmetric temporal integration of layer 4 and layer 2/3 inputs in visual cortex.Journal of neurophysiology · 2011Article
- Article
- Role of A-type potassium currents in excitability, network synchronicity, and epilepsy.Hippocampus · 2010Article
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The manner in which the thousands of synaptic inputs received by a pyramidal neuron are summed is critical both to our understanding of the computations that may be performed by single neurons and of the codes used by neurons to transmit information. Recent work on pyramidal cell dendrites has shown that subthreshold synaptic inputs are modulated by voltage-dependent channels, raising the possibility that summation of synaptic responses is influenced by the active properties of dendrites. Here, we use somatic and dendritic whole-cell recordings to show that pyramidal cells in hippocampal area CA3 sum distal and proximal excitatory postsynaptic potentials sublinearly and actively, that the degree of nonlinearity depends on the magnitude and timing of the excitatory postsynaptic potentials, and that blockade of transient potassium channels linearizes summation. Nonlinear summation of synaptic inputs could have important implications for the computations performed by single neurons and also for the role of the mossy fiber and perforant path inputs to hippocampal area CA3.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.