ArticleProceedings of the National Academy of Sciences of the United States of America1998
Tests and estimates of allelic association in complex inheritance.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
47 citing papers in PubMed.
- Association of Polymorphisms in Endothelial Nitric Oxide Synthesis and Renin-Angiotensin-Aldosterone System with Developing of Coronary Artery Disease in Bulgarian Patients.Genetic testing and molecular biomarkers · 2016Trial
- Association between Tourette syndrome and the dopamine D3 receptor gene rs6280.Chinese medical journal · 2015Article
- Gender specific association of RAS gene polymorphism with essential hypertension: a case-control study.BioMed research international · 2014Article
- Article
- Article
- Systems biology and heart failure: concepts, methods, and potential research applications.Heart failure reviews · 2010Review
- The Internet-based MGS2 control sample: self report of mental illness.The American journal of psychiatry · 2010Article
- PCA-based bootstrap confidence interval tests for gene-disease association involving multiple SNPs.BMC genetics · 2010Article
- DRD4 and DAT1 in ADHD: Functional neurobiology to pharmacogenetics.Pharmacogenomics and personalized medicine · 2010Article
- Correcting for cryptic relatedness in population-based association studies of continuous traits.Human heredity · 2010Article
- Recent advances in genetic predisposition to clinical acute lung injury.American journal of physiology. Lung cellular and molecular physiology · 2009Review
- Analysis of renin-angiotensin aldosterone system gene polymorphisms in Malaysian essential hypertensive and type 2 diabetic subjects.Cardiovascular diabetology · 2009Article
- Allelic association: linkage disequilibrium structure and gene mapping.Molecular biotechnology · 2009Review
- Sequence variants in the PLEKHH2 region are associated with diabetic nephropathy in the GoKinD study population.Human genetics · 2008Article
- Maternal smoking and oral clefts: the role of detoxification pathway genes.Epidemiology (Cambridge, Mass.) · 2008Article
- Gene-centric genomewide association study via entropy.Genetics · 2008Article
- Comparison of population-based association study methods correcting for population stratification.PloS one · 2008Article
- Simultaneously correcting for population stratification and for genotyping error in case-control association studies.American journal of human genetics · 2007Article
- Efficacy assessment of SNP sets for genome-wide disease association studies.Nucleic acids research · 2007Article
- PedGenie: an analysis approach for genetic association testing in extended pedigrees and genealogies of arbitrary size.BMC bioinformatics · 2006Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Family-based procedures such as the transmission disequilibrium test (TDT) were motivated by concern that sample-based methods to map disease genes by allelic association are not robust to population stratification, migration, and admixture. Other factors to consider in designing a study of allelic association are specification of gene action in a weakly parametric model, efficiency, diagnostic reliability for hypernormal individuals, interest in linkage and imprinting, and sibship composition. Family-based samples lend themselves to the TDT despite its inefficiency compared with cases and unrelated normal controls. The TDT has an efficiency of 1/2 for parent-offspring pairs and 2/3 for father-mother-child trios. Against cases and hypernormal controls, the efficiency is only 1/6 on the null hypothesis. Although dependent on marker gene frequency and other factors, efficiency for hypernormal controls is always greater than for random controls. Efficiency of the TDT is increased in multiplex families and by inclusion of normal sibs, approaching a case-control design with normal but not hypernormal controls. Isolated cases favor unrelated controls, and only in exceptional populations would avoidance of stratification justify a family-based design to map disease genes by allelic association.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.