ArticleProceedings of the National Academy of Sciences of the United States of America1998
Allelic association under map error and recombinational heterogeneity: a tale of two sites.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed, 36 citations in OpenAlex.
- Fifty years of genetic epidemiology, with special reference to Japan.Journal of human genetics · 2006Review
- Cosmopolitan linkage disequilibrium maps.Human genomics · 2005Article
- Positional cloning by linkage disequilibrium.American journal of human genetics · 2004Article
- The first linkage disequilibrium (LD) maps: delineation of hot and cold blocks by diplotype analysis.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- A sequence-based integrated map of chromosome 22.Genome research · 2001Article
- The optimal measure of allelic association.Proceedings of the National Academy of Sciences of the United States of America · 2001Article
- Genetic epidemiology of single-nucleotide polymorphisms.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
- Allelic association between marker loci.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 3 countries.
Funding
Abstract
Recombination acts on the genetic map, not on the physical map. On the other hand, the physical map is usually more accurate. Choice of the genetic or physical map for positional cloning by allelic association depends on the goodness of fit of data to each map under an established model. Huntington disease illustrates the usual case in which the greater reliability of physical data outweighs recombinational heterogeneity. Hemochromatosis represents an exceptional case in which unrecognized recombinational heterogeneity retarded positional cloning for a decade. The Malecot model performs well for major genes, but no approach assuming either equilibrium or disequilibrium has been validated for oligogenes contributing to common disease. In this case of greatest interest, the power of allelic association relative to linkage is less clear than for major genes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.