ArticleProceedings of the National Academy of Sciences of the United States of America1998
Transgenic mice for interleukin 3 develop motor neuron degeneration associated with autoimmune reaction against spinal cord motor neurons.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 44 citations in OpenAlex.
- Nanotherapeutic Approaches of Interleukin-3 to Clear the α-Synuclein Pathology in Mouse Models of Parkinson's Disease.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Interleukin-3 coordinates glial-peripheral immune crosstalk to incite multiple sclerosis.Immunity · 2023Article
- M-MDSCFrontiers in immunology · 2023Article
- Assessment of faithful interleukin-3 production by novel bicistronic interleukin-3 reporter mice.Immunology letters · 2020Article
- Anti-CTLA-4 synergizes with dendritic cell-targeted vaccine to promote IL-3-dependent CD4Annals of the New York Academy of Sciences · 2019Article
- CNS inflammation and neurodegeneration.The Journal of clinical investigation · 2017Article
- IL-3 promotes the development of experimental autoimmune encephalitis.JCI insight · 2016Article
- A xenograft model of macrophage activation syndrome amenable to anti-CD33 and anti-IL-6R treatment.JCI insight · 2016Article
- Pathways and gene networks mediating the regulatory effects of cannabidiol, a nonpsychoactive cannabinoid, in autoimmune T cells.Journal of neuroinflammation · 2016Article
- Intraperitoneally administered IgG from patients with amyotrophic lateral sclerosis or from an immune-mediated goat model increase the levels of TNF-α, IL-6, and IL-10 in the spinal cord and serum of mice.Journal of neuroinflammation · 2016Article
- Pivotal roles of GM-CSF in autoimmunity and inflammation.Mediators of inflammation · 2015Review
- STAT5 programs a distinct subset of GM-CSF-producing T helper cells that is essential for autoimmune neuroinflammation.Cell research · 2014Article
- Transgenic mouse models of multiple sclerosis.Cellular and molecular life sciences : CMLS · 2010Review
- Inflammation in ALS and SMA: sorting out the good from the evil.Neurobiology of disease · 2010Review
- Interaction between interleukin 3 and dystrobrevin-binding protein 1 in schizophrenia.Schizophrenia research · 2008Article
- Association study of CSF2RB with schizophrenia in Irish family and case - control samples.Molecular psychiatry · 2008Article
- Restricted expression of G86R Cu/Zn superoxide dismutase in astrocytes results in astrocytosis but does not cause motoneuron degeneration.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2000Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Interleukin 3 (IL-3) stimulates the proliferation and differentiation of various haematopoietic progenitor cells. Recently, IL-3 and other cytokines were reported to exert a neurotrophic activity and to be associated with neurological disorders, suggesting their complex role in the central nervous system. We now show that overexpression of IL-3 in transgenic mice causes a motor neuron disease with several features of amyotrophic lateral sclerosis and progressive muscular atrophy. These animals exhibit hind limb paralysis at 7 months of age, associated with dendritic and axonal degeneration, loss of motor neurons in the spinal cord, and autoimmune reaction against these cells. We examined the effect of IL-3 on embryonic motor neurons survival in mixed spinal cord cultures. Our results suggest that motor neuronal degeneration is not directly triggered by the high level of expression of IL-3.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.