ArticleProceedings of the National Academy of Sciences of the United States of America1998
Regulatory dysfunction of the interleukin-2 receptor during HIV infection and the impact of triple combination therapy.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 57 citations in OpenAlex.
- Decreased CD95 expression on naive T cells from HIV-infected persons undergoing highly active anti-retroviral therapy (HAART) and the influence of IL-2 low dose administration. Irhan Study Group.Clinical and experimental immunology · 2000Trial
- PLA2G1B is involved in CD4 anergy and CD4 lymphopenia in HIV-infected patients.The Journal of clinical investigation · 2020Article
- Blocking Formation of the Stable HIV Reservoir: A New Perspective for HIV-1 Cure.Frontiers in immunology · 2019Review
- HIV-1 infection increases microRNAs that inhibit Dicer1, HRB and HIV-EP2, thereby reducing viral replication.PloS one · 2019Article
- Rapid down-regulation of γc on T cells in early SIV infection correlates with impairment of T-cell function.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2012Article
- Characteristics of plasmacytoid dendritic cell and CD4+ T cell in HIV elite controllers.Clinical & developmental immunology · 2012Review
- HIV controllers: a multifactorial phenotype of spontaneous viral suppression.Clinical immunology (Orlando, Fla.) · 2011Review
- HIV infection of thymocytes inhibits IL-7 activity without altering CD127 expression.Retrovirology · 2011Article
- Opposite effects of high and low doses of interleukin-2 on T cell-mediated hepatitis in mice (interleukin-2 on hepatitis).Hepatology international · 2010Article
- Late expression of granulysin by microbicidal CD4+ T cells requires PI3K- and STAT5-dependent expression of IL-2Rbeta that is defective in HIV-infected patients.Journal of immunology (Baltimore, Md. : 1950) · 2008Article
- Longitudinal microarray analysis of cell surface antigens on peripheral blood mononuclear cells from HIV+ individuals on highly active antiretroviral therapy.Retrovirology · 2008Article
- IL-2 signals through Sgk1 and inhibits proliferation and apoptosis in kidney cancer cells.Journal of molecular medicine (Berlin, Germany) · 2007Article
- Associations of the IL2Ralpha, IL4Ralpha, IL10Ralpha, and IFN (gamma) R1 cytokine receptor genes with AIDS progression in a French AIDS cohort.Immunogenetics · 2006Article
- CD127 expression and regulation are altered in the memory CD8 T cells of HIV-infected patients--reversal by highly active anti-retroviral therapy (HAART).Clinical and experimental immunology · 2006Article
- Perturbations in B cell responsiveness to CD4+ T cell help in HIV-infected individuals.Proceedings of the National Academy of Sciences of the United States of America · 2003Article
- Human immunodeficiency virus-1 envelope glycoproteins and anti-CD4 antibodies inhibit interleukin-2-induced Jak/STAT signalling in human CD4 T lymphocytes.Clinical and experimental immunology · 2003Article
- Highly active antiretroviral therapy (HAART) and circulating markers of immune activation: specific effect of HAART on neopterin.Clinical and diagnostic laboratory immunology · 2000Article
- Impact of highly active anti-retroviral therapy (HAART) on cytokine production and monocyte subsets in HIV-infected patients.Clinical and experimental immunology · 2000Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
Abstract
The interleukin-2 (IL-2)/IL-2 receptor (IL-2R) system is the main regulatory determinant of T cell reactivity. Although it is well known that IL-2 secretion is impaired during HIV infection, up to now IL-2R expression has not been extensively studied in HIV-infected patients despite the use of IL-2 in clinical therapy trials. We show here that IL-2R expression in HIV patients with high viral load (group 1 in the study) is greatly enhanced on B lymphocytes, CD8 T lymphocytes, and monocytes, but not on CD4 T lymphocytes, compared with noninfected individuals. Paradoxically, this modified IL-2R expression does not lead to increased IL-2 responsiveness, except for B lymphocytes. In patients receiving triple combination therapy (TCT, two reverse transcriptase inhibitors and one protease inhibitor) that has triggered a drastic reduction in plasma viral load and an increase in CD4 counts (group 2 patients), IL-2R expression is significantly lower than in group 1 patients. Moreover, cells involved in cellular immunity and CD4 T lymphocytes have the capacity to respond to IL-2 after TCT. These results allow us to anticipate a beneficial role of IL-2 immunotherapy in combination with TCT.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.