ArticleProceedings of the National Academy of Sciences of the United States of America1998
Genetic code origins: tRNAs older than their synthetases?
Article in Proceedings of the National Academy of Sciences of the United States of America, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
24 citing papers in PubMed.
- Reduced Amino Acid Substitution Matrices Find Traces of Ancient Coding Alphabets in Modern Day Proteins.Molecular biology and evolution · 2025Article
- Peptide Bond Formation between Aminoacyl-Minihelices by a Scaffold Derived from the Peptidyl Transferase Center.Life (Basel, Switzerland) · 2022Article
- Evolutionary Adjustment of tRNA Identity Rules in Bacillariophyta for Recognition by an Aminoacyl-tRNA Synthetase Adds a Facet to the Origin of Diatoms.Journal of molecular evolution · 2022Article
- Driving forces in the origins of life.Open biology · 2021Article
- Peptidyl Transferase Center and the Emergence of the Translation System.Life (Basel, Switzerland) · 2017Article
- Evolution of initiator tRNAs and selection of methionine as the initiating amino acid.RNA biology · 2016Article
- Landmarks in the Evolution of (t)-RNAs from the Origin of Life up to Their Present Role in Human Cognition.Life (Basel, Switzerland) · 2015Review
- Normalization of Complete Genome Characteristics: Application to Evolution from Primitive Organisms to Homo sapiens.Current genomics · 2015Article
- Evidence for Natural Selection in Nucleotide Content Relationships Based on Complete Mitochondrial Genomes: Strong Effect of Guanine Content on Separation between Terrestrial and Aquatic Vertebrates.Current chemical genomics and translational medicine · 2015Article
- Does the genetic code have a eukaryotic origin?Genomics, proteomics & bioinformatics · 2013Article
- The RNA origin of transfer RNA aminoacylation and beyond.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2011Article
- Structure of an archaeal non-discriminating glutamyl-tRNA synthetase: a missing link in the evolution of Gln-tRNAGln formation.Nucleic acids research · 2010Article
- A mechanism for functional segregation of mitochondrial and cytosolic genetic codes.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Evolutionary patterns in the sequence and structure of transfer RNA: a window into early translation and the genetic code.PloS one · 2008Article
- Emergence of the universal genetic code imprinted in an RNA record.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- Nonorthologous replacement of lysyl-tRNA synthetase prevents addition of lysine analogues to the genetic code.Proceedings of the National Academy of Sciences of the United States of America · 2003Article
- Functional annotation of class I lysyl-tRNA synthetase phylogeny indicates a limited role for gene transfer.Journal of bacteriology · 2002Article
- Minihelix-loop RNAs: minimal structures for aminoacylation catalysts.Nucleic acids research · 2002Article
- A minihelix-loop RNA acts as a trans-aminoacylation catalyst.RNA (New York, N.Y.) · 2001Article
- An in vitro evolved precursor tRNA with aminoacylation activity.The EMBO journal · 2001Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
We present a phylogenetic analysis to determine whether a given tRNA molecule was established in evolution before its cognate aminoacyl-tRNA synthetase. The earlier appearance of tRNA versus their metabolically related enzymes is a prediction of the RNA world theory, but the available synthetase and tRNA sequences previously had not allowed a formal comparison of their relative time of appearance. Using data recently obtained from the emerging genome projects, our analysis points to the extant forms of lysyl-tRNA synthetase being preceded in evolution by the establishment of the identity of lysine tRNA.
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