ArticleProceedings of the National Academy of Sciences of the United States of America1998
Essential role of mitochondrially encoded large rRNA for germ-line formation in Drosophila embryos.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 83 citations in OpenAlex.
- Patterning the Drosophila embryo: A paradigm for RNA-based developmental genetic regulation.Wiley interdisciplinary reviews. RNA · 2020Review
- A Single Cell but Many Different Transcripts: A Journey into the World of Long Non-Coding RNAs.International journal of molecular sciences · 2020Review
- Long Oskar Controls Mitochondrial Inheritance in Drosophila melanogaster.Developmental cell · 2016Article
- Histone acetyltransferase Enok regulates oocyte polarization by promoting expression of the actin nucleation factor spire.Genes & development · 2014Article
- Control of cell differentiation by mitochondria, typically evidenced in dictyostelium development.Biomolecules · 2013Article
- BNC1 is required for maintaining mouse spermatogenesis.Genesis (New York, N.Y. : 2000) · 2012Article
- Doubly uniparental inheritance of mitochondria as a model system for studying germ line formation.PloS one · 2011Article
- Is the mitochondrial cloud the selection machinery for preferentially transmitting wild-type mtDNA between generations? Rewinding Müller's ratchet efficiently.Current genetics · 2010Review
- Subcellular distribution of mitochondrial ribosomal RNA in the mouse oocyte and zygote.PloS one · 2007Article
- Reproductive function for a C-terminus extended, male-transmitted cytochrome c oxidase subunit II protein expressed in both spermatozoa and eggs.FEBS letters · 2007Article
- l(3)malignant brain tumor and three novel genes are required for Drosophila germ-cell formation.Genetics · 2003Article
- A putative RNA editing from U to C in a mouse mitochondrial transcript.Nucleic acids research · 2002Article
- Presence of mitochondria-type ribosomes outside mitochondria in germ plasm of Drosophila embryos.Proceedings of the National Academy of Sciences of the United States of America · 2001Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In Drosophila, pole cells, the progenitors of the germ line, are induced by the factors localized in the posterior pole region of oocytes and cleavage embryos, or germ plasm. Polar granules in germ plasm are electron-dense structures and have been proposed to contain factors essential for pole cell formation. Mitochondrially encoded large ribosomal RNA (mtlrRNA) has been identified as a component of polar granules. We previously have shown that mtlrRNA is able to rescue embryos that fail to form pole cells as a result of UV irradiation. However, there is a possibility that the function of mtlrRNA is limited to UV-irradiated embryos, and the question of whether mtlrRNA is required for the normal pathway leading to pole cell formation remains unanswered. In this study, we report that the reduction of mtlrRNA in germ plasm by injecting anti-mtlrRNA ribozymes into cleavage embryos leads to their inability to form pole cells. Other components of germ plasm, namely oskar mRNA, germ cell-less mRNA, and Vasa and Tudor proteins appear to be unaffected in these ribozyme-injected embryos. These results support an essential role for mtlrRNA in pole cell formation. We propose that mitochondrially encoded molecules participate in a key event in early cell-type specification.
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