ArticleProceedings of the National Academy of Sciences of the United States of America1998
Transformation of hematopoietic cells by the Ski oncoprotein involves repression of retinoic acid receptor signaling.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
29 citing papers in PubMed, 65 citations in OpenAlex.
- PML-driven sumoylation of PML::RARA-bound repressors drives hematopoietic progenitor immortalization.The Journal of experimental medicine · 2026Article
- Repression of SMAD3 by STAT3 and c-Ski induces conventional dendritic cell differentiation.Life science alliance · 2024Article
- A toolbox for class I HDACs reveals isoform specific roles in gene regulation and protein acetylation.PLoS genetics · 2022Article
- Combined cistrome and transcriptome analysis of SKI in AML cells identifies SKI as a co-repressor for RUNX1.Nucleic acids research · 2018Article
- Strain-specific modifier genes governing craniofacial phenotypes.Birth defects research. Part A, Clinical and molecular teratology · 2012Article
- Chromosomal instability in mouse embryonic fibroblasts null for the transcriptional co-repressor Ski.Journal of cellular physiology · 2012Article
- Peroxisome proliferator-activated receptor γ (PPARγ) mediates a Ski oncogene-induced shift from glycolysis to oxidative energy metabolism.The Journal of biological chemistry · 2011Article
- A two-gene signature, SKI and SLAMF1, predicts time-to-treatment in previously untreated patients with chronic lymphocytic leukemia.PloS one · 2011Article
- The crystal structure of the Dachshund domain of human SnoN reveals flexibility in the putative protein interaction surface.PloS one · 2010Article
- The Ski protein negatively regulates Siah2-mediated HDAC3 degradation.Biochemical and biophysical research communications · 2010Article
- The Ski protein can inhibit ligand induced RARalpha and HDAC3 degradation in the retinoic acid signaling pathway.Biochemical and biophysical research communications · 2009Article
- Ski regulates muscle terminal differentiation by transcriptional activation of Myog in a complex with Six1 and Eya3.The Journal of biological chemistry · 2009Article
- Ski and SnoN, potent negative regulators of TGF-beta signaling.Cell research · 2009Review
- Ski can negatively regulates macrophage differentiation through its interaction with PU.1.Oncogene · 2008Article
- Identification of STRA6 and SKI sequence variants in patients with anophthalmia/microphthalmia.Molecular vision · 2008Article
- Article
- Deregulated TGF-beta signaling in leukemogenesis.Oncogene · 2005Review
- Distinct molecular phenotype of malignant CD34(+) hematopoietic stem and progenitor cells in chronic myelogenous leukemia.Oncogene · 2005Article
- The Ski oncoprotein is upregulated and localized at the centrosomes and mitotic spindle during mitosis.Oncogene · 2005Article
- Ski negatively regulates erythroid differentiation through its interaction with GATA1.Molecular and cellular biology · 2004Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 2 countries.
Funding
Abstract
The Ski oncogene has dramatic effects on the differentiation of several different cell types. It induces the differentiation of quail embryo cells into myoblasts and arrests the differentiation of chicken hematopoietic cells. The mechanism that Ski uses to carry out these disparate biological activities is unknown. However, we were struck by the similarity of these effects to those of certain members of the nuclear hormone receptor family. Both Ski and the thyroid hormone receptor-derived oncogene v-ErbA can arrest the differentiation of avian erythroblasts, and v-Ski-transformed avian multipotent progenitor cells resemble murine hematopoietic cells that express a dominant-negative form of the retinoic acid receptor, RARalpha. In this paper, we have tested the hypothesis that v-Ski and its cellular homologue c-Ski exert their effects by interfering with nuclear hormone receptor-induced transcription. We demonstrate that Ski associates with the RAR complex and can repress transcription from a retinoic acid response element. The physiological significance of this finding is demonstrated by the ability of high concentrations of a RARalpha-specific ligand to abolish v-Ski-induced transformation of the multipotent progenitors. These results strongly suggest that the ability of Ski to alter cell differentiation is caused in part by the modulation of RAR signaling pathways.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.