ArticleProceedings of the National Academy of Sciences of the United States of America1998
Synthesis, biophysical properties, and nuclease resistance properties of mixed backbone oligodeoxynucleotides containing cationic internucleoside guanidinium linkages: deoxynucleic guanidine/DNA chimeras.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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Who cites it
10 citing papers in PubMed.
- Impact of Positively Charged Backbone Modifications on the Properties of Spherical Nucleic Acids.Small (Weinheim an der Bergstrasse, Germany) · 2026Article
- Modified internucleoside linkages for nuclease-resistant oligonucleotides.RSC chemical biology · 2021Review
- Towards Zwitterionic Oligonucleotides with Improved Properties: the NAA/LNA-Gapmer Approach.Chembiochem : a European journal of chemical biology · 2020Article
- Mercury-Free Automated Synthesis of Guanidinium Backbone Oligonucleotides.Journal of the American Chemical Society · 2019Article
- Enhanced Stability of DNA Oligonucleotides with Partially Zwitterionic Backbone Structures in Biological Media.Molecules (Basel, Switzerland) · 2018Article
- Oligonucleotides with Cationic Backbone and Their Hybridization with DNA: Interplay of Base Pairing and Electrostatic Attraction.Chemistry (Weinheim an der Bergstrasse, Germany) · 2018Article
- Oligonucleotide analogues with cationic backbone linkages.Beilstein journal of organic chemistry · 2018Review
- NAA-modified DNA oligonucleotides with zwitterionic backbones: stereoselective synthesis of A-T phosphoramidite building blocks.Beilstein journal of organic chemistry · 2015Article
- (Pseudo)amide-linked oligosaccharide mimetics: molecular recognition and supramolecular properties.Beilstein journal of organic chemistry · 2010Article
- Solid-phase synthesis of oligopurine deoxynucleic guanidine (DNG) and analysis of binding with DNA oligomers.Nucleic acids research · 2001Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
The synthesis of mixed backbone oligodeoxynucleotides (18-mers) consisting of positively charged guanidinium linkages along with negatively charged phosphodiester linkages is carried out. The use of a base labile-protecting group for guanidinium linkage offers a synthetic strategy similar to standard oligonucleotide synthesis. The nuclease resistance of the oligodeoxyribonucleotides capped with guanidinium linkages at 5' and 3' ends are reported. The hybridization properties and sequence specificity of binding of these deoxynucleic guanidine/DNA chimeras with complementary DNA or RNA are described.
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