ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience1998
Critical role of axonal A-type K+ channels and axonal geometry in the gating of action potential propagation along CA3 pyramidal cell axons: a simulation study.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 47 citations in OpenAlex.
- Dynamics of excitability in axonal trees.Biophysical journal · 2026Article
- Spike-timing-dependent plasticity offers delay-gated oscillatory potentiation for autaptic weights.Frontiers in neural circuits · 2025Article
- A presynaptic source drives differing levels of surround suppression in two mouse retinal ganglion cell types.Nature communications · 2024Article
- The metabolic role of vagal afferent innervation.Nature reviews. Gastroenterology & hepatology · 2018Review
- An Optimized Structure-Function Design Principle Underlies Efficient Signaling Dynamics in Neurons.Scientific reports · 2018Article
- Microenvironmental regulation of oligodendrocyte replacement and remyelination in spinal cord injury.The Journal of physiology · 2016Review
- Branch specific and spike-order specific action potential invasion in basal, oblique, and apical dendrites of cortical pyramidal neurons.Neurophotonics · 2015Article
- Recurrent synapses and circuits in the CA3 region of the hippocampus: an associative network.Frontiers in cellular neuroscience · 2014Review
- Axonal properties determine somatic firing in a model of in vitro CA1 hippocampal sharp wave/ripples and persistent gamma oscillations.The European journal of neuroscience · 2012Article
- Beyond faithful conduction: short-term dynamics, neuromodulation, and long-term regulation of spike propagation in the axon.Progress in neurobiology · 2011Review
- Quantitative morphometry of electrophysiologically identified CA3b interneurons reveals robust local geometry and distinct cell classes.The Journal of comparative neurology · 2009Article
- Inside the brain of a neuron.EMBO reports · 2006Review
- Role of A-type K+ channels in spike broadening observed in soma and axon of Hermissenda type-B photoreceptors: a simulation study.Journal of computational neuroscience · 2006Article
- Determinants of action potential propagation in cerebellar Purkinje cell axons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2005Article
- Characterization of release-independent short-term depression in the juvenile rat hippocampus.The Journal of physiology · 2004Article
- Axonal propagation: does the spike stop here?The Journal of physiology · 2003Article
- Action potentials reliably invade axonal arbors of rat neocortical neurons.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
- Release-independent short-term synaptic depression in cultured hippocampal neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2000Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A model of CA3 pyramidal cell axons was used to study a new mode of gating of action potential (AP) propagation along the axon that depends on the activation of A-type K+ current (Debanne et al., 1997). The axonal membrane contained voltage-dependent Na+ channels, K+ channels, and A-type K+ channels. The density of axonal A-channels was first determined so that (1) at the resting membrane potential an AP elicited by a somatic depolarization was propagated into all axon collaterals and (2) propagation failures occurred when a brief somatic hyperpolarization preceded the AP induction. Both conditions were fulfilled only when A-channels were distributed in clusters but not when they were homogeneously distributed along the axon. Failure occurs in the proximal part of the axon. Conduction failure could be determined by a single cluster of A-channels, local decrease of axon diameter, or axonal elongation. We estimated the amplitude and temporal parameters of the hyperpolarization required for induction of a conduction block. Transient and small somatic hyperpolarizations, such as simulated GABAA inhibitory postsynaptic potentials, were able to block the AP propagation. It was shown that AP induction had to occur with a short delay (<30 msec) after the hyperpolarization. We discuss the possible conditions in which such local variations of the axon geometry and A-channel density may occur and the incidence of AP propagation failures on hippocampal network properties.
Indexed as
Identifiers
9736663PMC6793228W1512813107What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.