ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience1998
TrkB and neurotrophin-4 are important for development and maintenance of sympathetic preganglionic neurons innervating the adrenal medulla.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 49 citations in OpenAlex.
- To celebrate the 80th birthday of Klaus Unsicker: discovery of a new growth factor and studies on the effects of growth factors on adrenal chromaffin cells and neurons.Cell and tissue research · 2022Article
- ProNGF and Neurodegeneration in Alzheimer's Disease.Frontiers in neuroscience · 2019Review
- Generation of Adrenal Chromaffin-like Cells from Human Pluripotent Stem Cells.Stem cell reports · 2018Article
- Norepinephrine deficiency with normal blood pressure control in congenital insensitivity to pain with anhidrosis.Annals of neurology · 2015Article
- Article
- Brain-derived neurotrophic factor as a regulator of systemic and brain energy metabolism and cardiovascular health.Annals of the New York Academy of Sciences · 2012Review
- Development of the vagal innervation of the gut: steering the wandering nerve.Neurogastroenterology and motility · 2011Review
- Expression and Role of the BDNF Receptor-TrkB in Rat Adrenal Gland under Acute Immobilization Stress.Acta histochemica et cytochemica · 2010Article
- Chromaffin progenitor cells from the adrenal medulla.Cellular and molecular neurobiology · 2010Article
- Sodium depletion increases sympathetic neurite outgrowth and expression of a novel TMEM35 gene-derived protein (TUF1) in the rat adrenal zona glomerulosa.Endocrinology · 2010Article
- Mechanisms of synapse and dendrite maintenance and their disruption in psychiatric and neurodegenerative disorders.Annual review of neuroscience · 2010Review
- Characterization of trkB immunoreactive cells in the intermediolateral cell column of the rat spinal cord.Neuroscience letters · 2008Article
- Neurotrophic factors in autonomic nervous system plasticity and dysfunction.Neuromolecular medicine · 2008Review
- Neurotrophin-regulated signalling pathways.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2006Review
- Loss of leukemia inhibitory factor receptor beta or cardiotrophin-1 causes similar deficits in preganglionic sympathetic neurons and adrenal medulla.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2006Article
- Dietary restriction normalizes glucose metabolism and BDNF levels, slows disease progression, and increases survival in huntingtin mutant mice.Proceedings of the National Academy of Sciences of the United States of America · 2003Article
- Neurotrophin-4 deficient mice have a loss of vagal intraganglionic mechanoreceptors from the small intestine and a disruption of short-term satiety.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2001Article
- Lack of neurotrophin-4 causes selective structural and chemical deficits in sympathetic ganglia and their preganglionic innervation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2001Article
- Glial cell line-derived neurotrophic factor rescues target-deprived sympathetic spinal cord neurons but requires transforming growth factor-beta as cofactor in vivo.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1999Article
- Lingual innervation in male and female marmosets.Neurobiology of pain (Cambridge, Mass.)Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The adrenal medulla receives its major presynaptic input from sympathetic preganglionic neurons that are located in the intermediolateral (IML) column of the thoracic spinal cord. The neurotrophic factor concept would predict that these IML neurons receive trophic support from chromaffin cells in the adrenal medulla. We show here that adrenal chromaffin cells in the adult rat store neurotrophin (NT)-4, but do not synthesize or store detectable levels of BDNF or NT-3, respectively. Preganglionic neurons to the adrenal medulla identified by retrograde tracing with fast blue or Fluoro-Gold (FG) express TrkB mRNA. After unilateral destruction of the adrenal medulla, 24% of IML neurons, i.e., all neurons that are preganglionic to the adrenal medulla in spinal cord segments T7-T10, disappear. Administration of NT-4 in gelfoams (6 microgram) implanted into the medullectomized adrenal gland rescued all preganglionic neurons as evidenced by their presence after 4 weeks. NT-3 and cytochrome C were not effective. The action of NT-4 is accompanied by massive sprouting of axons in the vicinity of the NT-4 source as monitored by staining for acetylcholinesterase and synaptophysin immunoreactivity, suggesting that NT-4 may enlarge the terminal field of preganglionic nerves and enhance their access to trophic factors. Analysis of TrkB-deficient mice revealed degenerative changes in axon terminals on chromaffin cells. Furthermore, numbers of FG-labeled IML neurons in spinal cord segments T7-T10 of NT-4-deficient adult mice were significantly reduced. These data are consistent with the notion that NT-4 from chromaffin cells operates through TrkB receptors to regulate development and maintenance of the preganglionic innervation of the adrenal medulla.
Indexed as
Identifiers
9736648PMC6793231W1617847985What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.