ArticleThe EMBO journal1998
Apc10 and Ste9/Srw1, two regulators of the APC-cyclosome, as well as the CDK inhibitor Rum1 are required for G1 cell-cycle arrest in fission yeast.
Article in The EMBO journal, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed, 94 citations in OpenAlex.
- Article
- Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.Scientific reports · 2024Article
- Article
- Requirement of PP2A-B56iScience · 2020Article
- Protein Phosphatases in G1 Regulation.International journal of molecular sciences · 2020Review
- Regulation of Cell Cycle Entry and Exit: A Single Cell Perspective.Comprehensive Physiology · 2019Review
- Down-regulation of Cdk1 activity in G1 coordinates the G1/S gene expression programme with genome replication.Current genetics · 2019Review
- A novel function of anaphase promoting complex subunit 10 in tumor progression in non-small cell lung cancer.Cell cycle (Georgetown, Tex.) · 2019Article
- Anaphase-promoting complex/cyclosome regulates RdDM activity by degrading DMS3 inProceedings of the National Academy of Sciences of the United States of America · 2019Article
- How causal analysis can reveal autonomy in models of biological systems.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2017Article
- Phosphorylation of the RNA-binding protein Zfs1 modulates sexual differentiation in fission yeast.Journal of cell science · 2017Article
- TORC2 is required to maintain genome stability during S phase in fission yeast.The Journal of biological chemistry · 2013Article
- Experimental validation of Ankrd17 and Anapc10, two novel meiotic genes predicted by computational models in mice.Biology of reproduction · 2012Article
- Mathematical modeling of fission yeast Schizosaccharomyces pombe cell cycle: exploring the role of multiple phosphatases.Systems and synthetic biology · 2011Article
- Cubism and the cell cycle: the many faces of the APC/C.Nature reviews. Molecular cell biology · 2011Review
- Sequence characterization and promoter identification of porcine APC10 gene.Molecular biology reports · 2010Article
- Rab-family GTPase regulates TOR complex 2 signaling in fission yeast.Current biology : CB · 2010Article
- Rab small GTPase emerges as a regulator of TOR complex 2.Small GTPases · 2010Article
- Proteasome nuclear import mediated by Arc3 can influence efficient DNA damage repair and mitosis in Schizosaccharomyces pombe.Molecular biology of the cell · 2010Article
- Coupling histone homeostasis to centromere integrity via the ubiquitin-proteasome system.Cell division · 2010Article
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Many eukaryotic cells arrest the cell cycle at G1 phase upon nutrient deprivation. In fission yeast, during nitrogen starvation, cells divide twice and arrest at G1. We have isolated a novel type of sterile mutant, which undergoes one additional S phase upon starvation and, as a result, arrests at G2. Three loci (apc10, ste9/srw1 and rum1) were identified. The apc10 mutants, previously unidentified, show, in addition to sterility, temperature-sensitive growth with defects in chromosome segregation. apc10(+) is essential for viability, encodes a conserved protein (a homologue of budding yeast Apc10/Doc1) and is required for ubiquitination and degradation of mitotic B-type cyclins. Apc10 does not co-sediment with the 20S APC-cyclosome, a ubiquitin ligase for B-type cyclins, and in the apc10 mutant the 20S complex is intact, suggesting that it is a novel regulator for this complex. A subpopulation of Apc10 does co-immunoprecipitate with the anaphase-promoting complex (APC). A second gene, ste9(+)/srw1(+), encodes a member of the fizzy-related family, also regulators of the APC. Finally, Rum1 is a cyclin-dependent kinase (CDK) inhibitor which exists only in G1. The results suggest that dual downregulation of CDK, one via the APC and the other via the CDK inhibitor, is a universal mechanism that is used to arrest cell cycle progression at G1.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.