ArticleThe EMBO journal1998
Severe B cell deficiency and disrupted splenic architecture in transgenic mice expressing the E41K mutated form of Bruton's tyrosine kinase.
Article in The EMBO journal, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 62 citations in OpenAlex.
- Bruton's Tyrosine Kinase-Mediated Signaling in Myeloid Cells Is Required for Protective Innate Immunity During Pneumococcal Pneumonia.Frontiers in immunology · 2021Article
- Map3k14 as a Regulator of Innate and Adaptive Immune Response during Acute Viral Infection.Pathogens (Basel, Switzerland) · 2020Article
- Switch-like activation of Bruton's tyrosine kinase by membrane-mediated dimerization.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Role of Bruton's tyrosine kinase in B cells and malignancies.Molecular cancer · 2018Review
- Growth Hormone (GH) Deficient Mice With GHRH Gene Ablation Are Severely Deficient in Vaccine and Immune Responses AgainstFrontiers in immunology · 2018Article
- A novel oncogenic BTK isoform is overexpressed in colon cancers and required for RAS-mediated transformation.Oncogene · 2016Article
- CEACAM1 induces B-cell survival and is essential for protective antiviral antibody production.Nature communications · 2015Article
- Targeting Bruton's tyrosine kinase in B cell malignancies.Nature reviews. Cancer · 2014Review
- MicroRNAs prevent the generation of autoreactive antibodies.Immunity · 2010Article
- Rap1b regulates B cell development, homing, and T cell-dependent humoral immunity.Journal of immunology (Baltimore, Md. : 1950) · 2008Article
- The B cell antigen receptor controls integrin activity through Btk and PLCgamma2.The Journal of experimental medicine · 2003Article
- Protein kinase C beta controls nuclear factor kappaB activation in B cells through selective regulation of the IkappaB kinase alpha.The Journal of experimental medicine · 2002Article
- PKCbeta modulates antigen receptor signaling via regulation of Btk membrane localization.The EMBO journal · 2001Article
- Bruton's tyrosine kinase regulates the activation of gene rearrangements at the lambda light chain locus in precursor B cells in the mouse.The Journal of experimental medicine · 2001Article
- Severe B cell deficiency in mice lacking the tec kinase family members Tec and Btk.The Journal of experimental medicine · 2000Article
- Posttranscriptional regulation of Bruton's tyrosine kinase expression in antigen receptor-stimulated splenic B cells.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
- Murine MHC class II locus control region drives expression of human beta-glucocerebrosidase in antigen presenting cells of transgenic mice.Gene therapy · 1999Article
- In situ detection of activated Bruton's tyrosine kinase in the Ig signaling complex by phosphopeptide-specific monoclonal antibodies.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To identify B-cell signaling pathways activated by Bruton's tyrosine kinase (Btk) in vivo, we generated transgenic mice in which Btk expression is driven by the MHC class II Ea gene locus control region. Btk overexpression did not have significant adverse effects on B cell function, and essentially corrected the X-linked immunodeficiency (xid) phenotype in Btk- mice. In contrast, expression of a constitutively activated form of Btk carrying the E41K gain-of-function mutation resulted in a B cell defect that was more severe than xid. The mice showed a marked reduction of the B cell compartment in spleen, lymph nodes, peripheral blood and peritoneal cavity. The levels in the serum of most immunoglobulin subclasses decreased with age, and B cell responses to both T cell-independent type II and T cell-dependent antigens were essentially absent. Expression of the E41K Btk mutant enhanced blast formation of splenic B cells in vitro in response to anti-IgM stimulation. Furthermore, the mice manifested a disorganization of B cell areas and marginal zones in the spleen. Our findings demonstrate that expression of constitutively activated Btk blocks the development of follicular recirculating B cells.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.