ArticleAntimicrobial agents and chemotherapy1998
Identification of elongation factor 2 as the essential protein targeted by sordarins in Candida albicans.
Article in Antimicrobial agents and chemotherapy, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed.
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- Diterpenes Specially Produced by Fungi: Structures, Biological Activities, and Biosynthesis (2010-2020).Journal of fungi (Basel, Switzerland) · 2022Review
- Cell Wall Proteome Profiling of aMicroorganisms · 2021Article
- Three New Derivatives of Zopfinol fromJournal of fungi (Basel, Switzerland) · 2021Article
- A mutated dph3 gene causes sensitivity of Schizosaccharomyces pombe cells to cytotoxic agents.Current genetics · 2017Article
- Article
- Emerging drugs and vaccines for candidemia.Mycoses · 2014Review
- Optimization of zofimarin production by an endophytic fungus, Xylaria sp. Acra L38.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2014Article
- Purification, crystallization and preliminary X-ray analysis of adenylosuccinate synthetase from the fungal pathogen Cryptococcus neoformans.Acta crystallographica. Section F, Structural biology and crystallization communications · 2013Article
- Structural insights into the mechanism of translational inhibition by the fungicide sordarin.Journal of computer-aided molecular design · 2013Article
- An insight into the antifungal pipeline: selected new molecules and beyond.Nature reviews. Drug discovery · 2010Review
- Stm1p alters the ribosome association of eukaryotic elongation factor 3 and affects translation elongation.Nucleic acids research · 2009Article
- A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.Antimicrobial agents and chemotherapy · 2008Article
- Sordarin, an antifungal agent with a unique mode of action.Beilstein journal of organic chemistry · 2008Article
- Improvement of sordarin production through process optimization: combining traditional approaches with DOE.Journal of industrial microbiology & biotechnology · 2007Article
- Antifungal activities of R-135853, a sordarin derivative, in experimental candidiasis in mice.Antimicrobial agents and chemotherapy · 2005Article
- Ribosomal P0 protein domain involved in selectivity of antifungal sordarin derivatives.Antimicrobial agents and chemotherapy · 2004Article
- Chemosensitization of fluconazole resistance in Saccharomyces cerevisiae and pathogenic fungi by a D-octapeptide derivative.Antimicrobial agents and chemotherapy · 2004Article
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2 authors.
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Abstract
The target for sordarins in Candida albicans has been elucidated. Kinetic experiments of sordarin inhibition as well as displacement experiments showed that the formation of a sordarin-target complex follows a reversible mechanism. Binding of tritiated drug to the target is enhanced in the presence of ribosomes. Isolation of the target by classical protein purification methods has allowed us to identify it as elongation factor 2. This is in agreement with the nature of sordarin derivatives as specific inhibitors of the elongation cycle within protein synthesis in yeasts.
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