ArticleThe American journal of pathology1998
Telomerase activity and expression of telomerase RNA component and telomerase catalytic subunit gene in cervical cancer.
Article in The American journal of pathology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 102 citations in OpenAlex.
- Assessing telomerase and Ki-67 protein expression in pre-invasive lesions and invasive cervical neoplasia with correlation to clinico-pathological parameters.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026Article
- Escape from Cellular Senescence Is Associated with Chromosomal Instability in Oral Pre-Malignancy.Biology · 2023Review
- Review
- Progressive endothelin-1 gene activation initiates chronic/end-stage renal disease following experimental ischemic/reperfusion injury.Kidney international · 2013Article
- miR-138 overexpression is more powerful than hTERT knockdown to potentiate apigenin for apoptosis in neuroblastoma in vitro and in vivo.Experimental cell research · 2013Article
- Post-ischemic azotemia as a partial 'brake', slowing progressive kidney disease.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2013Article
- Detention of HPV L1 Capsid Protein and hTERC Gene in Screening of Cervical Cancer.Iranian journal of basic medical sciences · 2013Article
- Small nucleolar RNAs in cancer.Biochimica et biophysica acta · 2012Review
- The role of telomeres in the ageing of human skin.Experimental dermatology · 2011Review
- Cancer biomarkers: are we ready for the prime time?Cancers · 2010Article
- n-Butylidenephthalide induced apoptosis in the A549 human lung adenocarcinoma cell line by coupled down-regulation of AP-2alpha and telomerase activity.Acta pharmacologica Sinica · 2009Article
- Non-radioactive assay methods for the assessment of telomerase activity and telomere length.Methods in molecular biology (Clifton, N.J.) · 2009Article
- Downregulation of miR-138 is associated with overexpression of human telomerase reverse transcriptase protein in human anaplastic thyroid carcinoma cell lines.Cancer science · 2008Article
- Telomerase activity as an adjunct to high-risk human papillomavirus types 16 and 18 and cytology screening in cervical cancer.British journal of cancer · 2006Article
- Epigenetics of cervical cancer. An overview and therapeutic perspectives.Molecular cancer · 2005Review
- Increased hTR expression during transition from adenoma to carcinoma is not associated with promoter methylation.Digestive diseases and sciences · 2004Article
- Induction of hTERT expression and phosphorylation by estrogen via Akt cascade in human ovarian cancer cell lines.Oncogene · 2004Article
- Telomerase activity detected in oral lichen planus by RNA in situ hybridisation: not a marker for malignant transformation.Journal of clinical pathology · 2002Article
- Telomere and telomerase in the initial stage of immortalization of esophageal epithelial cell.World journal of gastroenterology · 2002Article
- Analysis of telomerase as a diagnostic biomarker of cervical dysplasia and carcinoma.Oncogene · 2002Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Telomerase, a ribonucleoprotein complex that includes the telomerase RNA component (hTR) and the telomerase catalytic subunit gene (hTERT) product, has been shown to be activated in the majority of cancer tissues and immortalized cells. To study telomerase activation during the progression of cervical cancer, the expression of hTR and hTERT RNAs in tissues of various stages of cervical cancer was analyzed using the in situ hybridization method and compared with proliferative activity as estimated by Ki-67 immunostaining. To test whether expression of these components is reflected in enzyme activity, we determined the levels of the RNAs in cervical cancer and normal tissues and in primary and immortal keratinocytes by reverse transcription-polymerase chain reaction and RNase protection assays and compared the results to telomerase activities as detected by telomeric repeat amplification protocol assay. In situ hybridization signals of hTR and hTERT were present not only in carcinoma tissues but also in normal epidermal layers. In many adenocarcinoma and fewer squamous cell carcinoma tissues, both signals were focally increased where high proliferative activity was present at the stages of dysplasia/metaplasia, in situ carcinoma, and invasive carcinoma. The level of bTERT, as quantitated by RNase protection assay, was not different between cancer and control tissues or immortal and a subset of primary keratinocytes and did not correlate with telomerase activity. These results indicate that expression of hTR and bTERT is up-regulated in at least a subset of neoplastic cells at an early stage of carcinogenesis and that unidentified factors, such as the modulation or coordination of its protein level with other products, may contribute to the activation of telomerase in cervical cancer.
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