ArticleThe American journal of pathology1998
Basic fibroblast growth factor is neither necessary nor sufficient for the development of retinal neovascularization.
Article in The American journal of pathology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 100 citations in OpenAlex.
- Article
- The effect of fibroblast growth factor 2 on neovascular vessels depends on the stage of angiogenesis.Heliyon · 2024Article
- Targeting angiogenesis in oncology, ophthalmology and beyond.Nature reviews. Drug discovery · 2023Review
- Limb functional recovery is impaired in fibroblast growth factor-2 (FGF2) deficient mice despite chronic ischaemia-induced vascular growth.Growth factors (Chur, Switzerland) · 2020Article
- Aqueous cytokine levels associated with severity of type 1 retinopathy of prematurity and treatment response to ranibizumab.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2018Article
- Retinopathy of prematurity: inflammation, choroidal degeneration, and novel promising therapeutic strategies.Journal of neuroinflammation · 2017Review
- Expression of leukemia inhibitory factor in Müller glia cells is regulated by a redox-dependent mRNA stability mechanism.BMC biology · 2015Article
- Expression patterning reveals retinal inflammation as a minor factor in experimental retinopathy of ZDF rats.Acta diabetologica · 2014Article
- Microvascular complications and diabetic retinopathy: recent advances and future implications.Future medicinal chemistry · 2013Review
- In vitro imaging of angiogenesis using embryonic stem cell-derived endothelial cells.Stem cells and development · 2012Article
- Parstatin suppresses ocular neovascularization and inflammation.Investigative ophthalmology & visual science · 2010Article
- Pleiotropic roles of matrix metalloproteinases in tumor angiogenesis: contrasting, overlapping and compensatory functions.Biochimica et biophysica acta · 2010Review
- Topical administration of a multi-targeted kinase inhibitor suppresses choroidal neovascularization and retinal edema.Journal of cellular physiology · 2008Article
- Vascular endothelial growth factor expression in the retinal pigment epithelium is essential for choriocapillaris development and visual function.The American journal of pathology · 2005Article
- Article
- Angiopoietin 1 inhibits ocular neovascularization and breakdown of the blood-retinal barrier.Gene therapy · 2004Article
- Ocular neovascularization: a valuable model system.Oncogene · 2003Review
- Targeted disruption of the Fgf2 gene does not affect vascular growth in the mouse ischemic hindlimb.Journal of applied physiology (Bethesda, Md. : 1985) · 2002Article
- Matrix metalloproteinase-9-dependent exposure of a cryptic migratory control site in collagen is required before retinal angiogenesis.The American journal of pathology · 2002Article
- Absence of fibroblast growth factor 2 does not prevent tumor formation originating from the RPE.Oncogene · 2002Article
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
Abstract
Basic fibroblast growth factor (FGF2) is constitutively expressed in the retina and its expression is increased by a number of insults, but its role in the retina is still uncertain. This study was designed to test the hypothesis that altered expression of FGF2 in the retina affects the development of retinal neovascularization. Mice with targeted disruption of the Fgf2 gene had no detectable expression of FGF2 in the retina by Western blot, but retinal vessels were not different in appearance or total area from wild-type mice. When FGF2-deficient mice were compared with wild-type mice in a murine model of oxygen-induced ischemic retinopathy, they developed the same amount of retinal neovascularization. Transgenic mice with a rhodopsin promoter/Fgf2 gene fusion expressed high levels of FGF2 in retinal photoreceptors but developed no retinal neovascularization or other abnormalities of retinal vessels; in the ischemic retinopathy model, they showed no significant difference in the amount of retinal neovascularization compared with wild-type mice. These data indicate that FGF2 expression is not necessary nor sufficient for the development of retinal neovascularization. This suggests that agents that specifically antagonize FGF2 are not likely to be useful adjuncts in the treatment of retinal neovascularization and therapies designed to increase FGF2 expression are not likely to be complicated by retinal neovascularization.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.