ArticleThe American journal of pathology1998
Trisomy 3 is not a common feature in malignant lymphomas of mucosa-associated lymphoid tissue type.
Article in The American journal of pathology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 56 citations in OpenAlex.
- Recent Advances in the Genetic of MALT Lymphomas.Cancers · 2021Review
- Epidemiological characterization, genetic alterations of Helicobacter pylori infection in chronic gastric disorder and prognostic values of heterozygosity loss in chromosome 3p.Molecular biology reports · 2019Article
- Management of gastric mucosa-associated lymphoid tissue lymphoma in patients with extra copies of theWorld journal of gastroenterology · 2017Article
- Molecular Aspects of H. pylori-Related MALT Lymphoma.Pathology research international · 2011Article
- Fluorescence in situ hybridization (FISH) analysis of primary ocular adnexal MALT lymphoma.BMC cancer · 2006Article
- Molecular pathogenesis of MALT lymphoma: two signaling pathways underlying the antiapoptotic effect of API2-MALT1 fusion protein.Leukemia · 2006Review
- Complete or partial trisomy 3 in gastro-intestinal MALT lymphomas co-occurs with aberrations at 18q21 and correlates with advanced disease stage: a study on 25 cases.World journal of gastroenterology · 2005Article
- Trisomy 3 may predict a poor response of gastric MALT lymphoma to Helicobacter pylori eradication therapy.World journal of gastroenterology · 2005Article
- 18q21 Rearrangement and trisomy 3 in extranodal B-cell lymphomas: a study using a fluorescent in situ hybridisation technique.Virchows Archiv : an international journal of pathology · 2004Article
- Unfavourable prognosis of patients with trisomy 18q21 detected by fluorescence in situ hybridisation in t(11;18) negative, surgically resected, gastrointestinal B cell lymphomas.Journal of clinical pathology · 2004Article
- Mucosa-associated lymphoid tissue lymphoma in the conjunctiva of a child.Virchows Archiv : an international journal of pathology · 2004Article
- Mucosa-associated lymphoid tissue lymphomas with t(11;18)(q21;q21) and mucosa-associated lymphoid tissue lymphomas with aneuploidy develop along different pathogenetic pathways.The American journal of pathology · 2002Article
- Mucosa-associated lymphoid tissue lymphomas.Current oncology reports · 2000Review
- Clinicopathological features of gastric mucosa associated lymphoid tissue (MALT) lymphomas: high grade transformation and comparison with diffuse large B cell lymphomas without MALT lymphoma features.Journal of clinical pathology · 2000Article
- Exclusive detection of the t(11;18)(q21;q21) in extranodal marginal zone B cell lymphomas (MZBL) of MALT type in contrast to other MZBL and extranodal large B cell lymphomas.The American journal of pathology · 1999Article
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The genetic background of extranodal marginal zone B-cell non-Hodgkin's lymphoma (NHL) of mucosa-associated lymphoid tissue (MALT) type is poorly understood. In contrast to most entities of primary nodal lymphomas, few cytogenetic data are available, and gene rearrangements frequently encountered in and highly characteristic of certain entities of systemic NHL are absent in this type of lymphoma. Recently, it was suggested that MALT-type NHLs are associated with certain numerical chromosome aberrations and especially with trisomy 3. We performed an extensive study using a sensitive double (bicolor) fluorescence in situ hybridization technique for the analysis of trisomies for chromosomes 3, 7, 12, and 18 in 60 samples of low-grade and 45 high-grade MALT-type tumors. In the low-grade cases, trisomy 3 was found in a frequency of only 20%. High-grade lymphomas of MALT type were associated with trisomies 3, 7, 12, and 18 in 36, 20, 18, and 13% of the cases, respectively. Whereas no difference was encountered for trisomy 3 in primary and secondary/simultaneous high-grade lymphomas, +7 and +12 were associated with primary lymphomas, and a +18 was predominantly found in secondary/simultaneous high-grade NHL. These results challenge earlier reports describing a high frequency of +3 in low-grade MALT-type NHL and indicate a possibly different genetic evolution pattern of primary and secondary/simultaneous high-grade lymphomas of primary mucosal origin.
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