ArticleJournal of virology1998
Proviral structure, chromosomal location, and expression of HERV-K-T47D, a novel human endogenous retrovirus derived from T47D particles.
Article in Journal of virology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 99 citations in OpenAlex.
- TE-SCALE: a comprehensive database for exploring transposable element expression across human cancers at single-cell resolution.Nucleic acids research · 2026Article
- Endogenous retroviral solo-LTRs in human genome.Frontiers in genetics · 2024Review
- Comprehensive identification and characterization of the HERV-K (HML-9) group in the human genome.Retrovirology · 2022Article
- HERV-K(HML7) Integrations in the Human Genome: Comprehensive Characterization and Comparative Analysis in Non-Human Primates.Biology · 2021Article
- Human Endogenous Retroviruses: Residues of Ancient Times Are Differentially Expressed in Crohn's Disease.Inflammatory intestinal diseases · 2019Article
- The HERV-K accessory protein Np9 controls viability and migration of teratocarcinoma cells.PloS one · 2019Article
- Promoter expression of HERV-K (HML-2) provirus-derived sequences is related to LTR sequence variation and polymorphic transcription factor binding sites.Retrovirology · 2018Article
- Susceptibility of Human Endogenous Retrovirus Type K to Reverse Transcriptase Inhibitors.Journal of virology · 2017Article
- Human endogenous retrovirus W env increases nitric oxide production and enhances the migration ability of microglia by regulating the expression of inducible nitric oxide synthase.Virologica Sinica · 2017Article
- The intron-enriched HERV-K(HML-10) family suppresses apoptosis, an indicator of malignant transformation.Mobile DNA · 2016Article
- Human Endogenous Retrovirus Type K (HERV-K) Particles Package and Transmit HERV-K-Related Sequences.Journal of virology · 2015Article
- Expansion of a novel endogenous retrovirus throughout the pericentromeres of modern humans.Genome biology · 2015Article
- ERVK polyprotein processing and reverse transcriptase expression in human cell line models of neurological disease.Viruses · 2015Article
- Inside the Envelope: Endogenous Retrovirus-K Env as a Biomarker and Therapeutic Target.Frontiers in microbiology · 2015Review
- Genomic flexibility of human endogenous retrovirus type K.Journal of virology · 2014Article
- The distribution of insertionally polymorphic endogenous retroviruses in breast cancer patients and cancer-free controls.Retrovirology · 2014Article
- HERV-K(HML-2), the Best Preserved Family of HERVs: Endogenization, Expression, and Implications in Health and Disease.Frontiers in oncology · 2013Review
- HIV infection reveals widespread expansion of novel centromeric human endogenous retroviruses.Genome research · 2013Article
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Corrections and comments
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We previously described that type B retrovirus-like particles released from the human mammary carcinoma cell line T47D are pseudotypes and package retroviral RNA of different origins (W. Seifarth, H. Skladny, F. Krieg-Schneider, A. Reichert, R. Hehlmann, and C. Leib-Mösch, J. Virol. 69:6408-6416, 1995). One preferentially packaged retroviral sequence, ERV-MLN, has now been used to isolate the corresponding full-length provirus from a human genomic library. The 9,315-bp proviral genome comprises a complete retroviral structure except for a 3' long terminal repeat (LTR) truncation. A lysine tRNA primer-binding site and phylogenetic analyses assign this human endogenous retroviral element, now called HERV-K-T47D, to the HML-4 subgroup of the HERV-K superfamily. The gag, prt, pol, and env genes exhibit 40 to 60% amino acid identity to HERV-K10. HERV-K-T47D is located on human chromosome 10, with five closely related elements on chromosomes 8, 9, 15, 16, and 19 and several hundred HERV-K-T47D-related solitary LTRs dispersed over the human genome. HERV-K-T47D-related sequences are detected in the genomes of higher primates and Old World monkeys but not in those of New World monkeys. High HERV-K-T47D transcription levels were observed in human placenta tissue, whereas transcription in T47D cells was strictly steroid dependent.
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