ArticleJournal of virology1998
Two novel adenovirus vector systems permitting regulated protein expression in gene transfer experiments.
Article in Journal of virology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed.
- Methods for gene transfer to the central nervous system.Advances in genetics · 2014Review
- Gene regulation systems for gene therapy applications in the central nervous system.Neurology research international · 2012Article
- A mouse model of inducible liver injury caused by tet-on regulated urokinase for studies of hepatocyte transplantation.The American journal of pathology · 2009Article
- Regulated expression of adenoviral vectors-based gene therapies: therapeutic expression of toxins and immune-modulators.Methods in molecular biology (Clifton, N.J.) · 2008Article
- Rescue and production of vaccine and therapeutic adenovirus vectors expressing inhibitory transgenes.Molecular biotechnology · 2007Article
- Synthetic tetracycline-inducible regulatory networks: computer-aided design of dynamic phenotypes.BMC systems biology · 2007Article
- Regulatable gene expression systems for gene therapy.Current gene therapy · 2006Review
- Cellular splicing and transcription regulatory protein p32 represses adenovirus major late transcription and causes hyperphosphorylation of RNA polymerase II.Journal of virology · 2006Article
- Regulatable gene expression systems for gene therapy applications: progress and future challenges.Molecular therapy : the journal of the American Society of Gene Therapy · 2005Review
- Liver-specific expression of interferon gamma following adenoviral gene transfer controls hepatitis B virus replication in mice.Gene therapy · 2005Article
- Establishment of an artificial beta-cell line expressing insulin under the control of doxycycline.World journal of gastroenterology · 2002Article
- Adenovirus vector designed for expression of toxic proteins.Journal of virology · 2001Article
- ICP0, ICP4, or VP16 expressed from adenovirus vectors induces reactivation of latent herpes simplex virus type 1 in primary cultures of latently infected trigeminal ganglion cells.Journal of virology · 2001Article
- Cisplatin induces the proapoptotic conformation of Bak in a deltaMEKK1-dependent manner.Molecular and cellular biology · 2001Article
- The adenovirus E4-ORF4 splicing enhancer protein interacts with a subset of phosphorylated SR proteins.The EMBO journal · 2001Article
- Overexpression of essential splicing factor ASF/SF2 blocks the temporal shift in adenovirus pre-mRNA splicing and reduces virus progeny formation.Journal of virology · 2000Article
- ERK signalling in metastatic human MDA-MB-231 breast carcinoma cells is adapted to obtain high urokinase expression and rapid cell proliferation.Clinical & experimental metastasis · 1999Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Two new adenovirus vector systems based on the tetracycline-regulated Tet-ON- (Gossen, M., et al., Science 268:1766-1769, 1995) and the RU 486-regulated progesterone antagonist (Wang, Y., et al., Proc. Natl. Acad. Sci. USA 91:8180-8184, 1994)-induced gene expression systems are described. We show that both systems permit a tight control of chloramphenicol acetyltransferase reporter gene expression in a variety of cell types, with induction levels of approximately 1,800-fold (Tet-ON system) and 600-fold (RU 486-regulated system), respectively. A significant advantage of our vector systems is that reporter protein expression can be adjusted over a wide range by varying the amount of inducer. The Tet-ON system is also shown to permit an efficient control of reporter gene expression in mice.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.