ArticleJournal of virology1998
The S2 gene of equine infectious anemia virus is dispensable for viral replication in vitro.
Article in Journal of virology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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Who cites it
26 citing papers in PubMed.
- Equine infectious anemia virus Mat protein serves as a Tat cofactor to facilitate viral transcription.Journal of virology · 2026Article
- Review
- Non-Primate Lentiviral Vectors and Their Applications in Gene Therapy for Ocular Disorders.Viruses · 2018Review
- S2 from equine infectious anemia virus is an infectivity factor which counteracts the retroviral inhibitors SERINC5 and SERINC3.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- SAMHD1 specifically restricts retroviruses through its RNase activity.Retrovirology · 2015Article
- Protective efficacy of centralized and polyvalent envelope immunogens in an attenuated equine lentivirus vaccine.PLoS pathogens · 2015Article
- A unique evolution of the s2 gene of equine infectious anemia virus in hosts correlated with particular infection statuses.Viruses · 2014Article
- Equine tetherin blocks retrovirus release and its activity is antagonized by equine infectious anemia virus envelope protein.Journal of virology · 2014Article
- Restriction of diverse retroviruses by SAMHD1.Retrovirology · 2013Article
- Challenges and proposed solutions for more accurate serological diagnosis of equine infectious anaemia.The Veterinary record · 2013Article
- Article
- Development of an equine-tropic replication-competent lentivirus assay for equine infectious anemia virus-based lentiviral vectors.Human gene therapy methods · 2012Article
- Divergence, not diversity of an attenuated equine lentivirus vaccine strain correlates with protection from disease.Vaccine · 2010Article
- Genomic analysis of an effective lentiviral vaccine-attenuated equine infectious anemia virus vaccine EIAV FDDV13.Virus genes · 2010Article
- Identification of cellular proteins interacting with equine infectious anemia virus S2 protein.Virus research · 2010Article
- EIAV S2 enhances pro-inflammatory cytokine and chemokine response in infected macrophages.Virology · 2010Article
- Restriction of equine infectious anemia virus by equine APOBEC3 cytidine deaminases.Journal of virology · 2009Article
- Envelope variation as a primary determinant of lentiviral vaccine efficacy.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- Immune suppression of challenged vaccinates as a rigorous assessment of sterile protection by lentiviral vaccines.Vaccine · 2007Article
- Discerning an effective balance between equine infectious anemia virus attenuation and vaccine efficacy.Journal of virology · 2005Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Equine infectious anemia virus (EIAV) contains the simplest genome among lentiviruses in that it encodes only three putative regulatory genes (S1, S2, S3) in addition to the canonical gag, pol, and env genes, presumably reflecting its limited tropism to cells of monocyte/macrophage lineage. Tat and Rev functions have been assigned to S1 and S3, respectively, but the specific function for the S2 gene has yet to be determined. Thus, the function of S2 in virus replication in vitro was investigated by using an infectious molecular viral clone, EIAVUK. Various EIAVUK mutants lacking S2 were constructed, and their replication kinetics were examined in several equine cell culture systems, including the natural in vivo target equine macrophage cells. The EIAV S2 mutants showed replication kinetics similar to those of the parental virus in all of the tested primary and transformed equine cell cultures, without any detectable reversion of mutant genomes. The EIAVUK mutants also showed replication kinetics similar to those of the parental virus in an equine blood monocyte differentiation-maturation system. These results demonstrate for the first time that the EIAV S2 gene is not essential and does not appear to affect virus infection and replication properties in target cells in vitro.
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