ArticleJournal of virology1998
Measles virus fusion protein is palmitoylated on transmembrane-intracytoplasmic cysteine residues which participate in cell fusion.
Article in Journal of virology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 45 citations in OpenAlex.
- The CP123L protein of African swine fever virus is a membrane-associated, palmitoylated protein required for viral replication.Journal of virology · 2025Article
- Recapitulating the potential contribution of protein S-palmitoylation in cancer.Cancer metastasis reviews · 2024Review
- Protein Palmitoylation Modification During Viral Infection and Detection Methods of Palmitoylated Proteins.Frontiers in cellular and infection microbiology · 2022Review
- Mass spectrometry-based investigation of measles and mumps virus proteome.Virology journal · 2018Article
- Paramyxovirus glycoprotein incorporation, assembly and budding: a three way dance for infectious particle production.Viruses · 2014Review
- Palmitoylation of virus proteins.Biology of the cell · 2012Review
- Function of membrane rafts in viral lifecycles and host cellular response.Biochemistry research international · 2011Article
- The Autographa californica multicapsid nucleopolyhedrovirus GP64 protein: analysis of transmembrane domain length and sequence requirements.Journal of virology · 2009Article
- The measles virus fusion protein transmembrane region modulates availability of an active glycoprotein complex and fusion efficiency.Journal of virology · 2008Article
- In situ tumor vaccination with adenovirus vectors encoding measles virus fusogenic membrane proteins and cytokines.World journal of gastroenterology · 2007Article
- Synergy between expression of fusogenic membrane proteins, chemotherapy and facultative virotherapy in colorectal cancer.Gene therapy · 2006Article
- Unusual topological arrangement of structural motifs in the baboon reovirus fusion-associated small transmembrane protein.Journal of virology · 2005Article
- Palmitoylation, membrane-proximal basic residues, and transmembrane glycine residues in the reovirus p10 protein are essential for syncytium formation.Journal of virology · 2003Article
- Virus entry, assembly, budding, and membrane rafts.Microbiology and molecular biology reviews : MMBR · 2003Review
- The transmembrane domain and cytoplasmic tail of herpes simplex virus type 1 glycoprotein H play a role in membrane fusion.Journal of virology · 2002Article
- The S4 genome segment of baboon reovirus is bicistronic and encodes a novel fusion-associated small transmembrane protein.Journal of virology · 2002Article
- Palmitoylation of the Rous sarcoma virus transmembrane glycoprotein is required for protein stability and virus infectivity.Journal of virology · 2001Article
- Adaptive mutations in Sindbis virus E2 and Ross River virus E1 that allow efficient budding of chimeric viruses.Journal of virology · 2000Article
- Measles virus structural components are enriched into lipid raft microdomains: a potential cellular location for virus assembly.Journal of virology · 2000Article
- Palmitoylation of the 25-kDa synaptosomal protein (SNAP-25) in vitro occurs in the absence of an enzyme, but is stimulated by binding to syntaxin.The Biochemical journal · 2000Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
[3H]palmitic acid was metabolically incorporated into the viral fusion protein (F) of Edmonston or freshly isolated measles virus (MV) during infection of human lymphoid or Vero cells. The uncleaved precursor F0 and the F1 subunit from infected cells and extracellular virus were both labeled, indicating that palmitoylation can take place prior to F0 cleavage and that palmitoylated F protein was incorporated into virus particles. [3H]palmitic acid was released from F protein upon hydroxylamine or dithiothreitol treatment, indicating a thioester linkage. In cells transfected with the cloned MV F gene, in which the cysteines located in the intracytoplasmic and transmembrane domains (Cys 506, 518, 519, 520, and 524) were replaced by serine, a major reduction of [3H]palmitic acid incorporation was observed for F mutated at Cys 506 and, to a lesser extent, at Cys 518 and Cys 524. We also observed incorporation of [3H]palmitic acid in the F1 subunit of canine distemper virus F protein. Cell fusion induced by cotransfection of cells with MV F and H (hemagglutinin) genes was significantly reduced after replacement of Cys 506 or Cys 519 with serine in the MV F gene. Transfection with the F gene with a mutation for Cys 518 abolished cell fusion, although less mutant protein was detected on the cell surface. These results suggest that the F protein transmembrane domain cysteines 506 and 518 participate in structures involved in cell fusion, possibly mediated by palmitoylation.
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