ArticleJournal of bioenergetics and biomembranes1998
Binding of rat brain hexokinase to recombinant yeast mitochondria: effect of environmental factors and the source of porin.
Article in Journal of bioenergetics and biomembranes, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 21 citations in OpenAlex.
- Engineering an Injectable Scaffold with Enhanced ECM Mimicry for Cell Delivery and Tissue Regeneration.ACS biomaterials science & engineering · 2025Article
- Hexokinase 1 cellular localization regulates the metabolic fate of glucose.Molecular cell · 2022Article
- Glycogen synthase kinase-3β opens mitochondrial permeability transition pore through mitochondrial hexokinase II dissociation.The journal of physiological sciences : JPS · 2018Article
- The structural and functional coordination of glycolytic enzymes in muscle: evidence of a metabolon?Biology · 2014Review
- Hexokinase II knockdown results in exaggerated cardiac hypertrophy via increased ROS production.EMBO molecular medicine · 2012Article
- Reduction in hexokinase II levels results in decreased cardiac function and altered remodeling after ischemia/reperfusion injury.Circulation research · 2011Article
- Regulation of hexokinase binding to VDAC.Journal of bioenergetics and biomembranes · 2008Review
- Glucose phosphorylation and mitochondrial binding are required for the protective effects of hexokinases I and II.Molecular and cellular biology · 2008Article
- The hepatitis E virus Orf3 protein protects cells from mitochondrial depolarization and death.The Journal of biological chemistry · 2007Article
- In self-defence: hexokinase promotes voltage-dependent anion channel closure and prevents mitochondria-mediated apoptotic cell death.The Biochemical journal · 2004Article
- Binding of rat brain hexokinase to recombinant yeast mitochondria: identification of necessary molecular determinants.Journal of bioenergetics and biomembranes · 1999Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Heterologous binding of rat brain hexokinase to wild type, porinless, and recombinant yeast mitochondria expressing human porin was assessed, partially characterized, and compared to that in the homologous system (rat liver mitochondria). With porin-containing yeast mitochondria it is shown that (i) a significant, saturable association occurs; (ii) its extent and apparent affinity, correlated with the origin of porin, are enhanced in the presence of dextran; (iii) the binding requires Mg ions and apparently follows a complex cooperative mechanism. This heterologous association does not seem to differ fundamentally from that in the homologous system and represents a good basis for molecular studies in yeast. With porinless yeast mitochondria, binding occurs at much lower affinity, but to many more sites per mitochondrion. The results indicating a major but not exclusive role for porin in the binding are discussed in terms of (i) the mode and mechanism of binding, and (ii) the suitability of the rat hexokinase-yeast mitochondria couple for the study of heterogeneous catalysis in reconstituted cellular model systems.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.