ArticleThe Journal of cell biology1998
ZAP-70 tyrosine kinase is required for LFA-1-dependent T cell migration.
Article in The Journal of cell biology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 72 citations in OpenAlex.
- RNAi library screening reveals Gβ1, Casein Kinase 2 and ICAP-1 as novel regulators of LFA-1-mediated T cell polarity and migration.Immunology and cell biology · 2025Article
- Profiling of human lymphocytes reveals a specific network of protein kinases modulated by endurance training status.Scientific reports · 2020Article
- CCR7 Is Recruited to the Immunological Synapse, Acts as Co-stimulatory Molecule and Drives LFA-1 Clustering for Efficient T Cell Adhesion Through ZAP70.Frontiers in immunology · 2018Article
- LFA-1 Engagement Triggers T Cell Polarization at the HIV-1 Virological Synapse.Journal of virology · 2016Article
- The Role of Crk Adaptor Proteins in T-Cell Adhesion and Migration.Frontiers in immunology · 2015Review
- ZAP70: a master regulator of adaptive immunity.Seminars in immunopathology · 2010Review
- T cell specific adapter protein (TSAd) interacts with Tec kinase ITK to promote CXCL12 induced migration of human and murine T cells.PloS one · 2010Article
- LFA-1-dependent Ca2+ entry following suboptimal T cell receptor triggering proceeds without mobilization of intracellular Ca2+.The Journal of biological chemistry · 2009Article
- Regulation of T cell integrin function by adapter proteins.Immunologic research · 2008Review
- CXCR3-mediated T-cell chemotaxis involves ZAP-70 and is regulated by signalling through the T-cell receptor.Immunology · 2007Article
- Article
- Signal transduction events regulating integrin function and T cell migration: new functions and complexity.Immunologic research · 2003Review
- CD28 plays a critical role in the segregation of PKC theta within the immunologic synapse.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- Retention of CXCR4 in the endoplasmic reticulum blocks dissemination of a T cell hybridoma.The Journal of clinical investigation · 2001Article
- Regulation of cytokine signaling by B cell antigen receptor and CD40-controlled expression of heparan sulfate proteoglycans.The Journal of experimental medicine · 2000Article
- The oncogenic 70Z Cbl mutation blocks the phosphotyrosine binding domain-dependent negative regulation of ZAP-70 by c-Cbl in Jurkat T cells.Molecular and cellular biology · 1999Article
- T cell receptor signaling pathway is overexpressed in CD4(+) T cells from HAM/TSP individuals.The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious DiseasesArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The ZAP-70 tyrosine kinase is essential for T cell activation by the T cell receptor. We show that ZAP-70 is also required for migration of T cells that is dependent on the integrin LFA-1. Invasion of TAM2D2 T cell hybridoma cells into fibroblast monolayers, which is LFA-1-dependent, was blocked by overexpression of dominant-negative ZAP-70 and by piceatannol but not by herbimycin A. The Syk inhibitor piceatannol blocks the Syk homologue ZAP-70, which is expressed by TAM2D2 cells, with the same dose dependence as the inhibition of invasion. Dominant-negative ZAP-70 completely inhibited the extensive metastasis formation of TAM2D2 cells to multiple organs upon i.v. injection into mice. Migration of TAM2D2 cells through filters coated with the LFA-1 ligand ICAM-1, induced by 1 ng/ml of the chemokine SDF-1, was blocked by anti-LFA-1 mAb and also abrogated by dominant-negative ZAP-70 and piceatannol. In contrast, migration induced by 100 ng/ml SDF-1 was independent of both LFA-1 and ZAP-70. LFA-1 cross-linking induced tyrosine phosphorylation, which was blocked by dominant-negative ZAP-70 and piceatannol. We conclude that LFA-1 engagement triggers ZAP-70 activity that is essential for LFA-1-dependent migration.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.