ArticleGenes & development1998
Transcription occurs in pulses in muscle fibers.
Article in Genes & development, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 76 papers.
What it found
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Who cites it
76 citing papers in PubMed, 203 citations in OpenAlex.
- Interplay between microtubule interactome, myonuclei mechanotransduction, and positioning in myopathies.Nucleus (Austin, Tex.) · 2025Review
- Three-dimensional imaging studies in mice identify cellular dynamics of skeletal muscle regeneration.Developmental cell · 2024Article
- Characterization of Skeletal Muscle Regeneration Revealed a Novel Growth Network Induced by Molecular Acupuncture-like Transfection.Biomolecules · 2024Review
- mRNA in situ hybridization exhibits unbalanced nuclear/cytoplasmic dystrophin transcript repartition in Duchenne myogenic cells and skeletal muscle biopsies.Scientific reports · 2023Article
- Regenerating Myofibers after an Acute Muscle Injury: What Do We Really Know about Them?International journal of molecular sciences · 2023Review
- The myonuclear domain in adult skeletal muscle fibres: past, present and future.The Journal of physiology · 2023Review
- Muscle regeneration affects Adeno Associated Virus 1 mediated transgene transcription.Scientific reports · 2022Article
- Positional Context of Myonuclear Transcription During Injury-Induced Muscle Regeneration.Frontiers in physiology · 2022Article
- Skeletal muscle fibers count on nuclear numbers for growth.Seminars in cell & developmental biology · 2021Review
- mRNA distribution in skeletal muscle is associated with mRNA size.Journal of cell science · 2021Article
- Single-nucleus RNA-seq identifies transcriptional heterogeneity in multinucleated skeletal myofibers.Nature communications · 2020Article
- Single-nucleus transcriptomics reveals functional compartmentalization in syncytial skeletal muscle cells.Nature communications · 2020Article
- Muscle memory: myonuclear accretion, maintenance, morphology, and miRNA levels with training and detraining in adult mice.Journal of cachexia, sarcopenia and muscle · 2020Article
- Computational Assessment of Transport Distances in Living Skeletal Muscle Fibers Studied In Situ.Biophysical journal · 2020Article
- Single-nucleus RNA-seq and FISH identify coordinated transcriptional activity in mammalian myofibers.Nature communications · 2020Article
- Myogenic Cell Expression of Intercellular Adhesion Molecule-1 Contributes to Muscle Regeneration after Injury.The American journal of pathology · 2020Article
- Induction of a local muscular dystrophy using electroporation in vivo: an easy tool for screening therapeutics.Scientific reports · 2020Article
- Modeling the transport of nuclear proteins along single skeletal muscle cells.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Multiplex in situ hybridization within a single transcript: RNAscope reveals dystrophin mRNA dynamics.PloS one · 2020Article
- Transitional Hybrid Skeletal Muscle Fibers in Rat Soleus Development.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2019Article
16 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We report a novel mechanism of gene regulation in skeletal muscle fibers. Within an individual myofiber nucleus, not all muscle loci are transcriptionally active at a given time and loci are regulated independently. This phenomenon is particularly remarkable because the nuclei within a myofiber share a common cytoplasm. Both endogenous muscle-specific and housekeeping genes and transgenes are regulated in this manner. Therefore, despite the uniform protein composition of the contractile apparatus along the length of the fiber, the loci that encode this structure are not transcribed continuously. The total number of active loci for a particular gene is dynamic, changing during fetal development, regeneration, and in the adult, and potentially reflects the growth status of the fiber. The data reveal that transcription in particular stages of muscle fiber maturation occurs in pulses and is defined by a stochastic mechanism.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.