ArticleThe Journal of experimental medicine1998
Qa-1b binds conserved class I leader peptides derived from several mammalian species.
Article in The Journal of experimental medicine, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 84 citations in OpenAlex.
- The murine MHC-E molecule Qa-1Frontiers in immunology · 2026Article
- Murine cytomegalovirus downregulates ERAAP and induces an unconventional T cell response to self.Cell reports · 2023Article
- Qa-1Molecular cancer research : MCR · 2021Article
- T Cells Engaging the Conserved MHC Class Ib Molecule Qa-1Frontiers in immunology · 2018Article
- Targeting Innate-Like T Cells in Tuberculosis.Frontiers in immunology · 2016Review
- HLA reduces killer cell Ig-like receptor expression level and frequency in a humanized mouse model.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- Isoforms of the nonclassical class I MHC antigen H2-Q5 are enriched in brain and encode Qdm peptide.Immunogenetics · 2011Article
- HLA-E-restricted regulatory CD8(+) T cells are involved in development and control of human autoimmune type 1 diabetes.The Journal of clinical investigation · 2010Article
- The nonpolymorphic MHC Qa-1b mediates CD8+ T cell surveillance of antigen-processing defects.The Journal of experimental medicine · 2010Article
- MR1 antigen presentation to mucosal-associated invariant T cells was highly conserved in evolution.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Article
- Perceiving the avidity of T cell activation can be translated into peripheral T cell regulation.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- The CD94/NKG2 family of receptors: from molecules and cells to clinical relevance.Immunologic research · 2006Review
- An affinity/avidity model of peripheral T cell regulation.The Journal of clinical investigation · 2005Article
- Polymorphism and conservation of the genes encoding Qa1 molecules.Immunogenetics · 2004Article
- A GATA factor mediates cell type-restricted induction of HLA-E gene transcription by gamma interferon.Molecular and cellular biology · 2004Article
- Suppression of autoimmune disease after vaccination with autoreactive T cells that express Qa-1 peptide complexes.The Journal of clinical investigation · 2004Article
- RT1.L: a family of MHC class Ib genes of the rat major histocompatibility complex with a distinct promoter structure.Immunogenetics · 2004Article
- Characterisation of RT1-E2, a multigenic family of highly conserved rat non-classical MHC class I molecules initially identified in cells from immunoprivileged sites.BMC immunology · 2003Article
- CD8+ T cells control the TH phenotype of MBP-reactive CD4+ T cells in EAE mice.Proceedings of the National Academy of Sciences of the United States of America · 2001Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Qa-1b binds a peptide (AMAPRTLLL), referred to as Qdm (for Qa-1 determinant modifier), derived from the signal sequence of murine class Ia molecules. This peptide binds with high affinity and accounts for almost all of the peptides associated with this molecule. Human histocompatibility leukocyte antigen (HLA)-E, a homologue of Qa-1b, binds similar peptides derived from human class Ia molecules and interacts with CD94/NKG2 receptors on natural killer cells. We used surface plasmon resonance to determine the ability of Qa-1b to bind related ligands representing peptides derived from the leaders of class I molecules from several mammalian species. All of the peptides reported to bind HLA-E bound readily to Qa-1b. In addition, peptides derived from leader segments of different mammals also bound to Qa-1b, indicating a conservation of this "Qdm-like" epitope throughout mammalian evolution. We have attempted to define a minimal peptide on a polyglycine backbone that binds Qa-1b. Our previous findings showed that P2 and P9 are important but not sufficient for binding to Qa-1b. Although a minimum peptide (GMGGGGLLL) bound Qa-1(b), its interaction was relatively weak, as were peptides sharing five or six residues with Qdm, indicating that multiple native residues are required for a strong interaction. This finding is consistent with the observation that this molecule preferentially binds this single ligand.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.