ArticleThe Journal of experimental medicine1998
Syk tyrosine kinase and B cell antigen receptor (BCR) immunoglobulin-alpha subunit determine BCR-mediated major histocompatibility complex class II-restricted antigen presentation.
Article in The Journal of experimental medicine, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 68 citations in OpenAlex.
- Inhibition of spleen tyrosine kinase decreases donor specific antibody levels in a rat model of sensitization.Scientific reports · 2022Article
- Dysfunctional BLK in common variable immunodeficiency perturbs B-cell proliferation and ability to elicit antigen-specific CD4+ T-cell help.Oncotarget · 2015Article
- Autonomic nervous system and immune system interactions.Comprehensive Physiology · 2014Review
- The Syk-binding ubiquitin ligase c-Cbl mediates signaling-dependent B cell receptor ubiquitination and B cell receptor-mediated antigen processing and presentation.The Journal of biological chemistry · 2012Article
- Therapeutic targeting of Syk in autoimmune diabetes.Journal of immunology (Baltimore, Md. : 1950) · 2010Article
- Actin-binding protein 1 regulates B cell receptor-mediated antigen processing and presentation in response to B cell receptor activation.Journal of immunology (Baltimore, Md. : 1950) · 2008Article
- The transmembrane tyrosine of micro-heavy chain is required for BCR destabilization and entry of antigen into clathrin-coated vesicles.International immunology · 2007Article
- Lipid rafts and B cell signaling.Seminars in cell & developmental biology · 2007Review
- Syk-dependent actin dynamics regulate endocytic trafficking and processing of antigens internalized through the B-cell receptor.Molecular biology of the cell · 2007Article
- Monovalent ligation of the B cell receptor induces receptor activation but fails to promote antigen presentation.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- Independent trafficking of Ig-alpha/Ig-beta and mu-heavy chain is facilitated by dissociation of the B cell antigen receptor complex.Journal of immunology (Baltimore, Md. : 1950) · 2005Article
- Dynamics of major histocompatibility complex class II compartments during B cell receptor-mediated cell activation.The Journal of experimental medicine · 2002Article
- Interference with immunoglobulin (Ig)alpha immunoreceptor tyrosine-based activation motif (ITAM) phosphorylation modulates or blocks B cell development, depending on the availability of an Igbeta cytoplasmic tail.The Journal of experimental medicine · 2001Article
- Specific immunotherapy of cancer in elderly patients.Drugs & aging · 2001Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Stimulation of CD4(+) helper T lymphocytes by antigen-presenting cells requires the degradation of exogenous antigens into antigenic peptides which associate with major histocompatibility complex (MHC) class II molecules in endosomal or lysosomal compartments. B lymphocytes mediate efficient antigen presentation first by capturing soluble antigens through clonally distributed antigen receptors (BCRs), composed of membrane immunoglobulin (Ig) associated with Ig-alpha/Ig-beta heterodimers which, second, target antigens to MHC class II-containing compartments. We report that antigen internalization and antigen targeting through the BCR or its Ig-alpha-associated subunit to newly synthesized class II lead to the presentation of a large spectrum of T cell epitopes, including some cryptic T cell epitopes. To further characterize the intracellular mechanisms of BCR-mediated antigen presentation, we used two complementary experimental approaches: mutational analysis of the Ig-alpha cytoplasmic tail, and overexpression in B cells of dominant negative syk mutants. Thus, we found that the syk tyrosine kinase, an effector of the BCR signal transduction pathway, is involved in the presentation of peptide- MHC class II complexes through antigen targeting by BCR subunits.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.