ReviewMicrobiology and molecular biology reviews : MMBR1998
Nutrient uptake by microorganisms according to kinetic parameters from theory as related to cytoarchitecture.
Review in Microbiology and molecular biology reviews : MMBR, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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Who cites it
45 citing papers in PubMed.
- Nutrient Supply Gradients Modulate Cultivation-Driven Restructuring of Microbial Communities in Desert Soils.Biology · 2026Article
- Comparative physiological and genomic characterization of a novelApplied and environmental microbiology · 2026Article
- Kinetic plasticity of nitrite-oxidizing bacteria containing cytoplasmic nitrite oxidoreductase.The ISME journal · 2026Article
- COmmunity and Single Microbe Optimisation System (COSMOS).NPJ systems biology and applications · 2025Article
- Growth of complete ammonia oxidizers on guanidine.Nature · 2024Article
- Ammonia-oxidizing bacteria and archaea exhibit differential nitrogen source preferences.Nature microbiology · 2024Article
- A probabilistic algorithm for optimising the steady-state diffusional flux into a partially absorbing body.Scientific reports · 2023Article
- Article
- Co-Occurrence and Cooperation between Comammox and Anammox Bacteria in a Full-Scale Attached Growth Municipal Wastewater Treatment Process.Environmental science & technology · 2023Article
- Bridging ribosomal synthesis to cell growth through the lens of kinetics.Biophysical journal · 2023Article
- Schindler's legacy: from eutrophic lakes to the phosphorus utilization strategies of cyanobacteria.FEMS microbiology reviews · 2022Review
- Impact of Microbial Uptake on the Nutrient Plume around Marine Organic Particles: High-Resolution Numerical Analysis.Microorganisms · 2022Article
- Article
- Glycine betaine uptake and metabolism in marine microbial communities.Environmental microbiology · 2022Article
- Limited Mechanistic Link Between the Monod Equation and Methanogen Growth: a Perspective from Metabolic Modeling.Microbiology spectrum · 2022Article
- Differential Responses of the Catalytic Efficiency of Ammonia and Nitrite Oxidation to Changes in Temperature.Frontiers in microbiology · 2022Article
- Ammonia-oxidizing archaea possess a wide range of cellular ammonia affinities.The ISME journal · 2022Article
- Multisubstrate DNA stable isotope probing reveals guild structure of bacteria that mediate soil carbon cycling.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Successful microbial colonization of space in a more dispersed manner.ISME communications · 2021Article
- Cellular costs underpin micronutrient limitation in phytoplankton.Science advances · 2021Article
Corrections and comments
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The abilities of organisms to sequester substrate are described by the two kinetic constants specific affinity, a degrees, and maximal velocity Vmax. Specific affinity is derived from the frequency of substrate-molecule collisions with permease sites on the cell surface at subsaturating concentrations of substrates. Vmax is derived from the number of permeases and the effective residence time, tau, of the transported molecule on the permease. The results may be analyzed with affinity plots (v/S versus v, where v is the rate of substrate uptake), which extrapolate to the specific affinity and are usually concave up. A third derived parameter, the affinity constant KA, is similar to KM but is compared to the specific affinity rather than Vmax and is defined as the concentration of substrate necessary to reduce the specific affinity by half. It can be determined in the absence of a maximal velocity measurement and is equal to the Michaelis constant for a system with hyperbolic kinetics. Both are taken as a measure of tau, with departure of KM from KA being affected by permease/enzyme ratios. Compilation of kinetic data indicates a 10(8)-fold range in specific affinities and a smaller (10(3)-fold) range in Vmax values. Data suggest that both specific affinities and maximal velocities can be underestimated by protocols which interrupt nutrient flow prior to kinetic analysis. A previously reported inverse relationship between specific affinity and saturation constants was confirmed. Comparisons of affinities with ambient concentrations of substrates indicated that only the largest a degreesS values are compatible with growth in natural systems.
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