ArticleThe Biochemical journal1998
Structure and organization of the human theta-class glutathione S-transferase and D-dopachrome tautomerase gene complex.
Article in The Biochemical journal, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 93 citations in OpenAlex.
- Variability of the Genes Involved in the Cellular Redox Status and Their Implication in Drug Hypersensitivity Reactions.Antioxidants (Basel, Switzerland) · 2021Review
- Esophageal cancer genetics in South Africa.Clinical and experimental gastroenterology · 2019Review
- Role of Glutathione S Transferase M1 and T1 Gene Polymorphism in Hepatitis B Related Liver Diseases and Cryptogenic Cirrhosis.Journal of clinical and experimental hepatology · 2018Article
- Association of GSTM1, GSTT1 and GSTP1 Ile105Val polymorphisms with clinical response to imatinib mesylate treatment among Malaysian chronic myeloid leukaemia patients.Journal of genetics · 2017Article
- The Genetic Architecture of Murine Glutathione Transferases.PloS one · 2016Article
- Haplotype differences for copy number variants in the 22q11.23 region among human populations: a pigmentation-based model for selective pressure.European journal of human genetics : EJHG · 2015Article
- Mice lacking three Loci encoding 14 glutathione transferase genes: a novel tool for assigning function to the GSTP, GSTM, and GSTT families.Drug metabolism and disposition: the biological fate of chemicals · 2014Article
- Association of maternal CNVs in GSTT1/GSTT2 with smoking, preterm delivery, and low birth weight.Frontiers in genetics · 2013Article
- Article
- Vitamin C levels in blood are influenced by polymorphisms in glutathione S-transferases.European journal of nutrition · 2011Article
- The D-dopachrome tautomerase (DDT) gene product is a cytokine and functional homolog of macrophage migration inhibitory factor (MIF).Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Article
- Genetic variations in human glutathione transferase enzymes: significance for pharmacology and toxicology.Human genomics and proteomics : HGP · 2010Article
- Cooperation between NRF-2 and YY-1 transcription factors is essential for triggering the expression of the PREPL-C2ORF34 bidirectional gene pair.BMC molecular biology · 2009Article
- Linkage disequilibrium between two high-frequency deletion polymorphisms: implications for association studies involving the glutathione-S transferase (GST) genes.PLoS genetics · 2009Article
- Review
- Microarray analysis of hepatic gene expression in gallstone-susceptible and gallstone-resistant mice.Mammalian genome : official journal of the International Mammalian Genome Society · 2003Article
- Cancer drugs, genetic variation and the glutathione-S-transferase gene family.American journal of pharmacogenomics : genomics-related research in drug development and clinical practice · 2003Review
- Identification and characterization of GSTT3, a third murine Theta class glutathione transferase.The Biochemical journal · 2002Article
- Macrophage migration inhibitory factor of the parasitic nematode Trichinella spiralis.The Biochemical journal · 2001Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The structure and organization of the human Theta-class glutathione S-transferase (GST) genes have been determined. GSTT1 and GSTT2 are separated by approx. 50 kb. They have a similar structure, being composed of five exons with identical exon/intron boundaries. GSTT1 is 8.1 kb in length, while GSTT2 is only 3.7 kb. The GSTT2 gene lies head-to-head with a gene encoding d-dopachrome tautomerase (DDCT), which extends over 8.5 kb and contains four exons. The sequence between GSTT2 and DDCT may contain a bidirectional promoter. The GSTT2 and DDCT genes have been duplicated in an inverted repeat. Sequence analysis of the duplicated GSTT2 gene has identified an exon 2/intron 2 splice site abnormality and a premature translation stop signal at codon 196. These changes suggest that the duplicate gene is a pseudogene, and it has been named GSTT2P.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.