ArticleJournal of the American Society of Nephrology : JASN1998
Renal Na/H exchanger NHE-3 and Na-PO4 cotransporter NaPi-2 protein expression in glucocorticoid excess and deficient states.
Article in Journal of the American Society of Nephrology : JASN, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 71 citations in OpenAlex.
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- Chronic ACTH Infusion Alters the Diurnal Rhythm of Sodium Excretion, Inducing Nondipping Blood Pressure and Salt-Sensitivity in Male Mice.Hypertension (Dallas, Tex. : 1979) · 2025Article
- [Pattern of biochemical markers of mineral and bone disorders in kidney transplant recipients: real-world data].Problemy endokrinologii · 2023Article
- C-FGF23 peptide alleviates hypoferremia during acute inflammation.Haematologica · 2021Article
- 1,25-Dihydroxyvitamin D Maintains Brush Border Membrane NaPi2a and Attenuates Phosphaturia in Hyp Mice.Endocrinology · 2019Article
- Mechanisms of phosphate transport.Nature reviews. Nephrology · 2019Review
- Phosphate and FGF-23 homeostasis after kidney transplantation.Nature reviews. Nephrology · 2015Review
- Glucocorticoids and renal Na+ transport: implications for hypertension and salt sensitivity.The Journal of physiology · 2014Review
- Phosphate metabolism and vitamin D.BoneKEy reports · 2014Article
- Chronic regulation of the renal Na(+)/H(+) exchanger NHE3 by dopamine: translational and posttranslational mechanisms.American journal of physiology. Renal physiology · 2013Article
- Sirolimus induced phosphaturia is not caused by inhibition of renal apical sodium phosphate cotransporters.PloS one · 2012Article
- Regulation of epithelial Na+ channels by adrenal steroids: mineralocorticoid and glucocorticoid effects.American journal of physiology. Renal physiology · 2012Article
- Tertiary excess of fibroblast growth factor 23 and hypophosphatemia following kidney transplantation.Pediatric transplantation · 2011Review
- Post-renal transplantation hypophosphatemia.Pediatric nephrology (Berlin, Germany) · 2010Review
- Luminal Na(+)/H (+) exchange in the proximal tubule.Pflugers Archiv : European journal of physiology · 2009Review
- Glucocorticoids acutely increase cell surface Na+/H+ exchanger-3 (NHE3) by activation of NHE3 exocytosis.American journal of physiology. Renal physiology · 2005Article
- Maturation of the Na+/H+ antiporter (NHE3) in the proximal tubule of the hypothyroid adrenalectomized rat.American journal of physiology. Renal physiology · 2004Article
- Dopamine acutely decreases apical membrane Na/H exchanger NHE3 protein in mouse renal proximal tubule.Kidney international · 2003Article
- Concerted roles of SGK1 and the Na+/H+ exchanger regulatory factor 2 (NHERF2) in regulation of NHE3.Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology · 2003Review
- Ontogeny of Na+/H+ antiporter activity in rat proximal convoluted tubules.Pediatric research · 2000Article
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Authors and funding
10 authors at 1 institution in 1 country.
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Abstract
Administration of pharmacologic doses of glucocorticoid in vivo increases renal proximal tubule apical membrane Na/H exchange and decreases Na/PO4 cotransport activity (1). Current data suggest that the NHE-3 and NaPi-2 proteins mediate significant fractions of proximal tubule apical membrane Na/H exchange and Na/PO4 cotransport, respectively. This study examines whether glucocorticoid excess or deficiency affects NHE-3 and NaPi-2 protein abundance and the intrarenal distribution of these transporters. Protein abundance of NHE-3 and NaPi-2 in control rats was compared to rats rendered glucocorticoid-deficient by bilateral adrenalectomy, and to rats receiving pharmacologic doses of dexamethasone using immunoblots and immunohistochemistry. Adrenalectomy had modest effects on NHE-3 protein abundance, but dexamethasone administration to either adrenalectomized or sham-operated rats significantly increased NHE-3 protein abundance in both the proximal tubule and thick ascending limb, but not the thin descending limb. Adrenalectomy increased NaPi-2 protein abundance in the proximal tubule, whereas dexamethasone administration dramatically suppressed NaPi-2 protein on the apical membrane in both adrenalectomized and sham-operated animals. No significant reciprocal increase in subapical NaPi-2 staining was seen in the dexamethasone-treated rats. The present study shows that glucocorticoids regulate proximal tubule apical membrane Na/H exchange and NaPi cotransport by changes in protein abundance of NHE-3 and NaPi-2, respectively.
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