ArticleThe Journal of clinical investigation1998
Vbeta4(+) T cells promote clearance of infection in murine pulmonary histoplasmosis.
Article in The Journal of clinical investigation, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 26 citations in OpenAlex.
- Article
- Histoplasma virulence and host responses.International journal of microbiology · 2012Article
- Histoplasma capsulatum at the host-pathogen interface.Microbes and infection · 2008Review
- A monoclonal antibody to Histoplasma capsulatum alters the intracellular fate of the fungus in murine macrophages.Eukaryotic cell · 2008Article
- V beta1+ J beta1.1+/V alpha2+ J alpha49+ CD4+ T cells mediate resistance against infection with Blastomyces dermatitidis.Infection and immunity · 2007Article
- Characterization of the Histoplasma capsulatum-induced granuloma.Journal of immunology (Baltimore, Md. : 1950) · 2006Article
- Diversity of the T-cell response to pulmonary Cryptococcus neoformans infection.Infection and immunity · 2006Article
- Pulmonary V beta 4+ T cells from Histoplasma capsulatum-infected mice respond to a homologue of Sec31 that confers a protective response.The Journal of infectious diseases · 2006Article
- Apoptosis modulates protective immunity to the pathogenic fungus Histoplasma capsulatum.The Journal of clinical investigation · 2005Article
- A deficiency in gamma interferon or interleukin-10 modulates T-Cell-dependent responses to heat shock protein 60 from Histoplasma capsulatum.Infection and immunity · 2005Article
- Vbeta14(+) T cells mediate the vaccine-enhanced disease induced by immunization with respiratory syncytial virus (RSV) G glycoprotein but not with formalin-inactivated RSV.Journal of virology · 2004Article
- Discordance between T-cell receptor expression and effector function in mice infected with Histoplasma capsulatum.Infection and immunity · 2002Article
- Protective efficacy of H antigen from Histoplasma capsulatum in a murine model of pulmonary histoplasmosis.Infection and immunity · 2001Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
T cells are essential for controlling infection with Histoplasma capsulatum. Because the T cell receptor is vital for transducing the biological activities of these cells, we sought to determine if exposure to this fungus induced an alteration in the Vbeta repertoire in lungs of C57BL/6 mice infected intranasally. Vbeta2(+) cells were elevated on day 3 after infection; Vbeta4(+) cells were higher than controls on days 7, 10, and 14 after infection. Vbeta10(+) cells were increased on days 14 and 21, and Vbeta11(+) exceeded controls only on day 14. We investigated the clonality and function of Vbeta4(+) cells because their expansion transpired during the critical time of infection, that is, when cellular immunity is activated. Sequence analysis demonstrated preferential use of a restricted set of sequences in the complementarity-determining region 3. Elimination of Vbeta4(+) cells from mice impaired their ability to resolve infection. In contrast, depletion of Vbeta7(+) cells, the abundance of which was similar to that of Vbeta4(+), did not alter elimination of the fungus. The identification of clonotypes of Vbeta4(+) cells suggests that a few antigenic determinants may drive proliferation of this subset, which is necessary for optimal clearance.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.