ArticleBiophysical journal1998
The size of the unstirred layer as a function of the solute diffusion coefficient.
Article in Biophysical journal, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.
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Who cites it
54 citing papers in PubMed.
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- Thickness of the aqueous boundary layer in stirred microtitre plate permeability assays (PAMPA and Caco-2), based on the Levich equation.ADMET & DMPK · 2022Article
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- Fast Permeation of Small Ions in Carbon Nanotubes.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021Article
- Passive Permeability of Planar Lipid Bilayers to Organic Anions.Biophysical journal · 2018Article
- Review
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
By monitoring the concentration distribution of several solutes that are diffusing at the same time under given mixing conditions, it was established that the unstirred layer (USL) has no clearly defined boundary. For the cases of solute permeation and water movement across planar bilayer lipid membranes, respectively, experiments carried out with double-barreled microelectrodes have shown that the thickness of the USL depends on which species is diffusing. Small molecules with a larger diffusion coefficient encounter an apparently thicker USL than larger molecules with a smaller diffusion coefficient. The ratio of the USL thicknesses of two different substances is equal to the third root of the ratio of the respective diffusion coefficients. This experimental finding is in good agreement with theoretical predictions from the theory of physicochemical hydrodynamics.
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