ArticleApplied and environmental microbiology1998
Induction of acid resistance of Salmonella typhimurium by exposure to short-chain fatty acids.
Article in Applied and environmental microbiology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 164 citations in OpenAlex.
- Roles of diet and the acid tolerance response in survival of common Salmonella serotypes in feces of finishing pigs.Applied and environmental microbiology · 2012Trial
- Dietary supplementation with a novel acidifier sodium diformate improves growth performance by increasing growth-related hormones levels and preventsFrontiers in veterinary science · 2024Article
- Controlling Salmonella: strategies for feed, the farm, and the processing plant.Poultry science · 2023Article
- Article
- The Different Response to an Acid Shock of TwoFrontiers in microbiology · 2021Article
- Gut Microbiota and Colonization Resistance against Bacterial Enteric Infection.Microbiology and molecular biology reviews : MMBR · 2019Review
- Dietary propionic acid enhances antibacterial and immunomodulatory effects of oxytetracycline on Nile tilapia, Oreochromis niloticus.Environmental science and pollution research international · 2018Article
- Impact of Prebiotics on Poultry Production and Food Safety.The Yale journal of biology and medicine · 2018Review
- Organic Acids and Potential for Modifying the Avian Gastrointestinal Tract and Reducing Pathogens and Disease.Frontiers in veterinary science · 2018Review
- Investigation of Medium Chain Fatty Acid Feed Supplementation for Reducing Salmonella Typhimurium Colonization in Turkey Poults.Foodborne pathogens and disease · 2017Article
- Adaptation inFrontiers in microbiology · 2016Review
- An Introduction to the Avian Gut Microbiota and the Effects of Yeast-Based Prebiotic-Type Compounds as Potential Feed Additives.Frontiers in veterinary science · 2015Review
- A review of the effects of dietary organic acids fed to swine.Journal of animal science and biotechnology · 2015Article
- Salmonella pathogenicity and host adaptation in chicken-associated serovars.Microbiology and molecular biology reviews : MMBR · 2013Review
- YfdW and YfdU are required for oxalate-induced acid tolerance in Escherichia coli K-12.Journal of bacteriology · 2013Article
- Article
- Article
- Immediate reduction of Salmonella enterica serotype typhimurium viability via membrane destabilization following exposure to multiple-hurdle treatments with heated, acidified organic acid salt solutions.Applied and environmental microbiology · 2011Article
- Proteomic analysis of Salmonella enterica serovar Enteritidis following propionate adaptation.BMC microbiology · 2010Article
- Perturbation of the small intestine microbial ecology by streptomycin alters pathology in a Salmonella enterica serovar typhimurium murine model of infection.Infection and immunity · 2009Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Exposure to short-chain fatty acids (SCFA) is one of the stress conditions Salmonella typhimurium encounters during its life cycle, because SCFA have been widely used as food preservatives and SCFA are also present at high concentrations in the gastrointestinal tracts of host animals. The effects of SCFA on the acid resistance of the organism were examined in an attempt to understand the potential role of SCFA in the pathogenesis of S. typhimurium. The percent survival of S. typhimurium at pH 3.0 was determined after exposure to SCFA for 1 h at pH 7.0. The percent acid survival, which varied depending on the SCFA species and the concentration used, was 42 after exposure to 100 mM propionate at pH 7.0 under aerobic incubation conditions, while less than 1% could survive without exposure. The SCFA-induced acid resistance was markedly enhanced by anaerobiosis (64%), lowering pH conditions (138% at pH 5.0), or increasing incubation time (165% with 4 h) during exposure to propionic acid. When protein synthesis during exposure to propionate was blocked by chloramphenicol, the percent acid survival was less than 1, indicating that the protein synthesis induced by exposure to propionate is required for the induction of the acid resistance. The percent acid survival determined with the isogenic mutant strains defective in acid tolerance response revealed that AtrB protein is necessary for the full induction of acid resistance by exposure to propionate, while unexpectedly, inactivation of PhoP significantly increased acid resistance over that of the wild type (P < 0.05). The results suggest that the virulence of S. typhimurium may be enhanced by increasing acid resistance upon exposure to SCFA during its life cycle and further enhanced by anaerobiosis, low pH, and prolonged exposure time.
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