ArticleMolecular biology of the cell1998
Activation of androgen receptor function by a novel nuclear protein kinase.
Article in Molecular biology of the cell, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
26 citing papers in PubMed, 116 citations in OpenAlex.
- Basic Leucine Zipper Transcription Factors as Important Regulators of Leydig Cells' Functions.International journal of molecular sciences · 2022Review
- AR-dependent phosphorylation and phospho-proteome targets in prostate cancer.Endocrine-related cancer · 2020Review
- Chromatin Targeting of HIPK2 Leads to Acetylation-Dependent Chromatin Decondensation.Frontiers in cell and developmental biology · 2020Article
- Functional impairment of the HIPK2 small ubiquitin-like modifier (SUMO)-interacting motif in acute myeloid leukemia.American journal of cancer research · 2019Article
- Effect of tyrosine autophosphorylation on catalytic activity and subcellular localisation of homeodomain-interacting protein kinases (HIPK).Cell communication and signaling : CCS · 2015Article
- Depletion of homeodomain-interacting protein kinase 3 impairs insulin secretion and glucose tolerance in mice.Diabetologia · 2012Article
- Luman/CREB3 recruitment factor regulates glucocorticoid receptor activity and is essential for prolactin-mediated maternal instinct.Molecular and cellular biology · 2012Article
- Death-associated protein 6 (Daxx) mediates cAMP-dependent stimulation of Cyp11a1 (P450scc) transcription.The Journal of biological chemistry · 2012Article
- Deciphering enzyme function using peptide arrays.Molecular biotechnology · 2011Review
- Discovering modulators of gene expression.Nucleic acids research · 2010Article
- Runx2 trans-activation mediated by the MSX2-interacting nuclear target requires homeodomain interacting protein kinase-3.Molecular endocrinology (Baltimore, Md.) · 2010Article
- A live zebrafish-based screening system for human nuclear receptor ligand and cofactor discovery.PloS one · 2010Article
- LKB1 catalytic activity contributes to estrogen receptor alpha signaling.Molecular biology of the cell · 2009Article
- Cyclin D3/CDK11p58 complex is involved in the repression of androgen receptor.Molecular and cellular biology · 2007Article
- Kinases and protein phosphorylation as regulators of steroid hormone action.Nuclear receptor signaling · 2007Review
- Cyclic AMP stimulates SF-1-dependent CYP11A1 expression through homeodomain-interacting protein kinase 3-mediated Jun N-terminal kinase and c-Jun phosphorylation.Molecular and cellular biology · 2007Article
- Overlapping roles for homeodomain-interacting protein kinases hipk1 and hipk2 in the mediation of cell growth in response to morphogenetic and genotoxic signals.Molecular and cellular biology · 2006Article
- Homeodomain-interacting protein kinase 1 modulates Daxx localization, phosphorylation, and transcriptional activity.Molecular and cellular biology · 2003Article
- An endocrine pathway in the prostate, ERbeta, AR, 5alpha-androstane-3beta,17beta-diol, and CYP7B1, regulates prostate growth.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- PIAS proteins modulate transcription factors by functioning as SUMO-1 ligases.Molecular and cellular biology · 2002Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Androgen receptor (AR) belongs to the nuclear receptor superfamily and mediates the biological actions of male sex steroids. In this work, we have characterized a novel 130-kDa Ser/Thr protein kinase ANPK that interacts with the zinc finger region of AR in vivo and in vitro. The catalytic kinase domain of ANPK shares considerable sequence similarity with the minibrain gene product, a protein kinase suggested to contribute to learning defects associated with Down syndrome. However, the rest of ANPK sequence, including the AR-interacting interface, exhibits no apparent homology with other proteins. ANPK is a nuclear protein that is widely expressed in mammalian tissues. Its overexpression enhances AR-dependent transcription in various cell lines. In addition to the zinc finger region, ligand-binding domain and activation function AF1 of AR are needed, as the activity of AR mutants devoid of these domains was not influenced by ANPK. The receptor protein does not appear to be a substrate for ANPK in vitro, and overexpression of ANPK does not increase the extent of AR phosphorylation in vivo. In view of this, it is likely that ANPK-mediated activation of AR function is exerted through modification of AR-associated proteins, such as coregulatory factors, and/or through stabilization of the receptor protein against degradation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.