ArticleGenetics1998
Quantitative trait loci affecting body weight and fatness from a mouse line selected for extreme high growth.
Article in Genetics, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
41 citing papers in PubMed, 133 citations in OpenAlex.
- Gene-by-environment Interactions and Adaptive Body Size Variation in Mice From the Americas.Molecular biology and evolution · 2025Article
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- Container-aided integrative QTL and RNA-seq analysis of Collaborative Cross mice supports distinct sex-oriented molecular modes of response in obesity.BMC genomics · 2020Article
- Article
- VARIABLE PRIORITIZATION IN NONLINEAR BLACK BOX METHODS: A GENETIC ASSOCIATION CASE STUDYThe annals of applied statistics · 2019Article
- Mapping novel genetic loci associated with female liver weight variations using Collaborative Cross mice.Animal models and experimental medicine · 2018Article
- Adiposity QTL Adip20 decomposes into at least four loci when dissected using congenic strains.PloS one · 2017Article
- Genetics of Rapid and Extreme Size Evolution in Island Mice.Genetics · 2015Article
- Genetic interactions with sex make a relatively small contribution to the heritability of complex traits in mice.PloS one · 2014Article
- Extrinsic and intrinsic regulation of DOR/TP53INP2 expression in mice: effects of dietary fat content, tissue type and sex in adipose and muscle tissues.Nutrition & metabolism · 2012Article
- Inferring genetic architecture of complex traits using Bayesian integrative analysis of genome and transcriptome data.BMC genomics · 2012Article
- Mapping of quantitative trait loci controlling lifespan in the short-lived fish Nothobranchius furzeri--a new vertebrate model for age research.Aging cell · 2012Article
- Fine-mapping alleles for body weight in LG/J × SM/J F₂ and F(34) advanced intercross lines.Mammalian genome : official journal of the International Mammalian Genome Society · 2011Article
- Metabolic responses to high-fat diets rich in n-3 or n-6 long-chain polyunsaturated fatty acids in mice selected for either high body weight or leanness explain different health outcomes.Nutrition & metabolism · 2011Article
- Article
- Admixture mapping of quantitative trait loci for BMI in African Americans: evidence for loci on chromosomes 3q, 5q, and 15q.Obesity (Silver Spring, Md.) · 2009Article
- An improved method for quantitative trait loci detection and identification of within-line segregation in F2 intercross designs.Genetics · 2008Article
- Genetic loci affecting body weight and fatness in a C57BL/6J x PWK/PhJ mouse intercross.Mammalian genome : official journal of the International Mammalian Genome Society · 2007Article
- Genetic control of lipids in the mouse cross DU6i x DBA/2.Mammalian genome : official journal of the International Mammalian Genome Society · 2007Article
- Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Quantitative trait loci (QTL) influencing body weight were mapped by linkage analysis in crosses between a high body weight selected line (DU6) and a control line (DUKs). The two mouse lines differ in body weight by 106% and in abdominal fat weight by 100% at 42 days. They were generated from the same base population and maintained as outbred colonies. Determination of line-specific allele frequencies at microsatellite markers spanning the genome indicated significant changes between the lines on 15 autosomes and the X chromosome. To confirm these effects, a QTL analysis was performed using structured F2 pedigrees derived from crosses of a single male from DU6 with a female from DUKs. QTL significant at the genome-wide level were mapped for body weight on chromosome 11; for abdominal fat weight on chromosomes 4, 11, and 13; for abdominal fat percentage on chromosomes 3 and 4; and for the weights of liver on chromosomes 4 and 11, of kidney on chromosomes 2 and 9, and of spleen on chromosome 11. The strong effect on body weight of the QTL on chromosome 11 was confirmed in three independent pedigrees. The effect was additive and independent of sex, accounting for 21-35% of the phenotypic variance of body weight within the corresponding F2 populations. The test for multiple QTL on chromosome 11 with combined data from all pedigrees indicated the segregation of two loci separated by 36 cM influencing body weight.
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Registered trials
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