ArticleGenetics1998
Molecular evolution of the Cecropin multigene family in Drosophila. functional genes vs. pseudogenes.
Article in Genetics, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed.
- Predictors of Protein Evolution in the drosophilid Immune System.Genome biology and evolution · 2026Article
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- Antibacterial Potential Analysis of Novel α-Helix Peptides in the Chinese Wolf SpiderPharmaceutics · 2022Article
- Comparative Genomics Reveals a Significant Sequence Variability of Myticin Genes inBiomolecules · 2020Article
- Antimicrobial peptides: Application informed by evolution.Science (New York, N.Y.) · 2020Review
- Insect Cecropins, Antimicrobial Peptides with Potential Therapeutic Applications.International journal of molecular sciences · 2019Review
- PTEN/PTENP1: 'Regulating the regulator of RTK-dependent PI3K/Akt signalling', new targets for cancer therapy.Molecular cancer · 2018Review
- A phylogenomic study quantifies competing mechanisms for pseudogenization in prokaryotes-The Mycobacterium leprae case.PloS one · 2018Article
- Involvement of cecropin B in the formation of the Aedes aegypti mosquito cuticle.Scientific reports · 2017Article
- The potential for adaptive maintenance of diversity in insect antimicrobial peptides.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2016Review
- HMGA1-pseudogenes and cancer.Oncotarget · 2016Review
- Convergent Balancing Selection on an Antimicrobial Peptide in Drosophila.Current biology : CB · 2016Article
- Pseudogenes: pseudo-functional or key regulators in health and disease?RNA (New York, N.Y.) · 2011Review
- Article
- Gene duplication and the genome distribution of sex-biased genes.International journal of evolutionary biology · 2011Article
- Functional regulatory divergence of the innate immune system in interspecific Drosophila hybrids.Molecular biology and evolution · 2010Article
- Molecular evolution of the cecropin multigene family in silkworm Bombyx mori.Bioinformation · 2010Article
- Article
- Article
- Gene expression divergence and evolutionary analysis of the drosomycin gene family in Drosophila melanogaster.Journal of biomedicine & biotechnology · 2009Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Approximately 4 kb of the Cecropin cluster region have been sequenced in nine lines of Drosophila melanogaster and one line of the sibling species D. simulans, D. mauritiana, and D. sechellia. This region includes three functional genes (CecA1, CecA2, and CecB), which are involved in the insect immune response, and two pseudogenes (CecPsi1 and CecPsi2). The level of silent polymorphism in the three Cec genes is rather high (0.028), and there is no excess of nonsynonymous polymorphism. There is no evidence of gene conversion in the history of these genes. The interspecific comparison has revealed that in the three species of the simulans cluster the CecA2 gene is partially deleted and has therefore lost its function and become a pseudogene; in each of the species, subsequent deletions have accumulated. Divergence estimates indicate that the CecPsi1 and CecPsi2 pseudogenes are highly diverged, both between themselves and relative to the other three Cec genes. However, both CecPsi1 and CecPsi2 have conserved transcriptional signals and splice sites, and they present an open reading frame; also, correctly spliced transcripts have been detected for both CecPsi1 and CecPsi2. The data support that these genes are either active genes with some null alleles or young pseudogenes.
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