ArticleProceedings of the National Academy of Sciences of the United States of America1998
Nociceptin/orphanin FQ-induced nociceptive responses through substance P release from peripheral nerve endings in mice.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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Who cites it
17 citing papers in PubMed, 113 citations in OpenAlex.
- Therapeutic potentials of NOP and MOP receptor coactivation for the treatment of pain and opioid abuse.Journal of neuroscience research · 2022Review
- Nociceptin is present in synovial fluid of patients undergoing total knee arthroplasty.Journal of orthopaedic surgery and research · 2020Article
- Sex Differences in Nociceptin/Orphanin FQ Peptide Receptor-Mediated Pain and Anxiety Symptoms in a Preclinical Model of Post-traumatic Stress Disorder.Frontiers in psychiatry · 2018Article
- Essential Neuroscience in Immunology.Journal of immunology (Baltimore, Md. : 1950) · 2017Review
- Comparison of NK-1 Receptor Antagonist (Maropitant) to Morphine as a Pre-Anaesthetic Agent for Canine Ovariohysterectomy.PloS one · 2015Article
- Differential effects of nociceptin/orphanin FQ (NOP) receptor agonists in acute versus chronic pain: studies with bifunctional NOP/μ receptor agonists in the sciatic nerve ligation chronic pain model in mice.The Journal of pharmacology and experimental therapeutics · 2011Article
- Parathyroid hormone 2 receptor is a functional marker of nociceptive myelinated fibers responsible for neuropathic pain.Journal of neurochemistry · 2010Article
- Stimulation of sensory neuropeptide release by nociceptin/orphanin FQ leads to hyperaemia in acutely inflamed rat knees.British journal of pharmacology · 2006Article
- Algogen-specific pain processing in mouse spinal cord: differential involvement of voltage-dependent Ca(2+) channels in synaptic transmission.British journal of pharmacology · 2002Article
- Anatomical and physiological evidence for involvement of tuberoinfundibular peptide of 39 residues in nociception.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- Nociceptin inhibits calcium channel currents in a subpopulation of small nociceptive trigeminal ganglion neurons in mouse.The Journal of physiology · 2001Article
- Protein kinase C-mediated inhibition of mu-opioid receptor internalization and its involvement in the development of acute tolerance to peripheral mu-agonist analgesia.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2001Article
- Enhanced spinal nociceptin receptor expression develops morphine tolerance and dependence.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2000Article
- Pharmacology of nociceptin and its receptor: a novel therapeutic target.British journal of pharmacology · 2000Review
- Enhanced nociception by exogenous and endogenous substance P given into the spinal cord in mice lacking NR(2)A/epsilon(1), an NMDA receptor subunit.British journal of pharmacology · 2000Article
- Effects of nociceptin and nocistatin on antidromic vasodilatation in hairless skin of the rat hindlimb in vivo.British journal of pharmacology · 1999Article
- The central questions in pain perception may be peripheral.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have studied the in vivo signaling mechanisms involved in nociceptin/orphanin FQ (Noci)-induced pain responses by using a flexor-reflex paradigm. Noci was 10,000 times more potent than substance P (SP) in eliciting flexor responses after intraplantar injection into the hind limb of mice, but the action of Noci seems to be mediated by SP. Mice pretreated with an NK1 tachykinin receptor antagonist or capsaicin, or mice with a targeted disruption of the tachykinin 1 gene no longer respond to Noci. The action of Noci appears to be mediated by the Noci receptor, a pertussis toxin-sensitive G protein-coupled receptor that stimulates inositol trisphosphate receptor and Ca2+ influx. These findings suggest that Noci indirectly stimulates nerve endings of nociceptive primary afferent neurons through a local SP release.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.