ArticleProceedings of the National Academy of Sciences of the United States of America1998
Generation of mucosal cytotoxic T cells against soluble protein by tissue-specific environmental and costimulatory signals.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
69 citing papers in PubMed, 125 citations in OpenAlex.
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- Hierarchal single-cell lineage tracing reveals differential fate commitment of CD8 T-cell clones in response to acute infection.bioRxiv : the preprint server for biology · 2024Article
- Memory T cells possess an innate-like function in local protection from mucosal infection.The Journal of clinical investigation · 2023Article
- Pyrimidine de novo synthesis inhibition selectively blocks effector but not memory T cell development.Nature immunology · 2023Article
- Intestinal CD8European journal of immunology · 2022Review
- Tissue resident memory T cells- A new benchmark for the induction of vaccine-induced mucosal immunity.Frontiers in immunology · 2022Review
- Pulmonary resident memory T cells in respiratory virus infection and their inspiration on therapeutic strategies.Frontiers in immunology · 2022Review
- Virus-based vaccine vectors with distinct replication mechanisms differentially infect and activate dendritic cells.NPJ vaccines · 2021Article
- PTPN2 Deficiency Enhances Programmed T Cell Expansion and Survival Capacity of Activated T Cells.Cell reports · 2020Article
- T cell engagement of cross-presenting microglia protects the brain from a nasal virus infection.Science immunology · 2020Article
- MicroRNA-155 Controls T Helper Cell Activation During Viral Infection.Frontiers in immunology · 2019Article
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- Long-lived tissue resident HIV-1 specific memory CD8Journal of controlled release : official journal of the Controlled Release Society · 2017Article
9 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We compared peripheral and mucosal primary CD8 T cell responses to inflammatory and noninflammatory forms of antigen in a T cell-adoptive transfer system. Immunization with the soluble antigen, ovalbumin (ova), administered i.p. or orally without adjuvant, activated nonmucosal CD8 T cells but did not induce cytotoxic activity. However, after activation, the transferred cells entered the intestinal mucosa and became potent antigen-specific killers. Thus, exogenous intact soluble protein entered the major histocompatibility complex class I antigen presentation pathway and induced mucosal cytotoxic T lymphocytes. Moreover, distinct costimulatory requirements for activation of peripheral versus mucosal T cells were noted in that the CD28 ligand, B7-1, was critical for activated mucosal T cell generation but not for activation of peripheral CD8 T cells. The costimulator, B7-2, was required for optimum activation of both populations. Infection with a new recombinant vesicular stomatitis virus encoding ovalbumin induced lytic activity in mucosal as well as peripheral sites, demonstrating an adjuvant effect of inflammatory mediators produced during virus infection. Generation of antiviral cytotoxic T lymphocytes was also costimulation-dependent. The results indicated that induction of peripheral tolerance via antigen administration may not extend to mucosal sites because of distinct costimulatory and inflammatory signals in the mucosa.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.