ArticleProceedings of the National Academy of Sciences of the United States of America1998
The Drosophila LIM-only gene, dLMO, is mutated in Beadex alleles and might represent an evolutionarily conserved function in appendage development.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 51 citations in OpenAlex.
- Beadex modulates haematopoiesis and innate immune defence against microbial infection in Drosophila melanogaster.Journal of cell science · 2026Article
- The Stage-Based Model of Addiction-UsingInternational journal of molecular sciences · 2023Review
- A Compilation of the Diverse miRNA Functions inInternational journal of molecular sciences · 2023Review
- Beadex affects gastric emptying in Drosophila.Cell research · 2014Article
- Beadex function in the motor neurons is essential for female reproduction in Drosophila melanogaster.PloS one · 2014Article
- HOX-mediated LMO2 expression in embryonic mesoderm is recapitulated in acute leukaemias.Oncogene · 2013Article
- Extent With Modification: Leg Patterning in the Beetle Tribolium castaneum and the Evolution of Serial Homologs.G3 (Bethesda, Md.) · 2012Article
- Repression of Lim only protein 4-activated transcription inhibits proliferation and induces apoptosis of normal mammary epithelial cells and breast cancer cells.Clinical & experimental metastasis · 2010Article
- A view from Drosophila: multiple biological functions for individual microRNAs.Seminars in cell & developmental biology · 2010Review
- miR-9a prevents apoptosis during wing development by repressing Drosophila LIM-only.Developmental biology · 2010Article
- Islet-to-LMO stoichiometries control the function of transcription complexes that specify motor neuron and V2a interneuron identity.Development (Cambridge, England) · 2009Article
- Drosophila, a genetic model system to study cocaine-related behaviors: a review with focus on LIM-only proteins.Neuropharmacology · 2009Review
- Chip is required for posteclosion behavior in Drosophila.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2008Article
- Drosophila LIM-only is a positive regulator of transcription during thoracic bristle development.Genetics · 2008Article
- Crystallization of an Lhx3-Isl1 complex.Acta crystallographica. Section F, Structural biology and crystallization communications · 2008Article
- A gain-of-function suppressor screen for genes involved in dorsal-ventral boundary formation in the Drosophila wing.Genetics · 2008Article
- Robustness and stability of the gene regulatory network involved in DV boundary formation in the Drosophila wing.PloS one · 2007Article
- LMO4 can interact with Smad proteins and modulate transforming growth factor-beta signaling in epithelial cells.Oncogene · 2006Article
- Human Bex2 interacts with LMO2 and regulates the transcriptional activity of a novel DNA-binding complex.Nucleic acids research · 2005Article
- Lmo mutants reveal a novel role for circadian pacemaker neurons in cocaine-induced behaviors.PLoS biology · 2004Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The process of wing patterning involves precise molecular mechanisms to establish an organizing center at the dorsal-ventral boundary, which functions to direct the development of the Drosophila wing. We report that misexpression of dLMO, a Drosophila LIM-only protein, in specific patterns in the developing wing imaginal disc, disrupts the dorsal-ventral (D-V) boundary and causes errors in wing patterning. When dLMO is misexpressed along the anterior-posterior boundary, extra wing outgrowth occurs, similar to the phenotype seen when mutant clones lacking Apterous, a LIM homeodomain protein known to be essential for normal D-V patterning of the wing, are made in the wing disc. When dLMO is misexpressed along the D-V boundary in third instar larvae, loss of the wing margin is observed. This phenotype is very similar to the phenotype of Beadex, a long-studied dominant mutation that we show disrupts the dLMO transcript in the 3' untranslated region. dLMO normally is expressed in the wing pouch of the third instar wing imaginal disc during patterning. A mammalian homolog of dLMO is expressed in the developing limb bud of the mouse. This indicates that LMO proteins might function in an evolutionarily conserved mechanism involved in patterning the appendages.
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