ArticleProceedings of the National Academy of Sciences of the United States of America1998
A potential mediator of collagenous block copolymer gradients in mussel byssal threads.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 87 citations in OpenAlex.
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- Intertidal Warfare: Synergistic Allelopathy Mediates Spatial Competition between Two Marine Calcareous-Shelled Sessile Organisms.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Recombinant Proteins: A Molecular Tool to Understand Marine Adhesion and to Advance Biomaterials.Advanced healthcare materials · 2026Review
- Prevention and Control of Biofouling Coatings inPolymers · 2024Review
- Protein-Based Biological Materials: Molecular Design and Artificial Production.Chemical reviews · 2023Review
- High Performance Marine and Terrestrial Bioadhesives and the Biomedical Applications They Have Inspired.Molecules (Basel, Switzerland) · 2022Review
- Genomics and Transcriptomics of the green mussel explain the durability of its byssus.Scientific reports · 2021Article
- Healing through Histidine: Bioinspired Pathways to Self-Healing Polymers via Imidazole⁻Metal Coordination.Biomimetics (Basel, Switzerland) · 2019Review
- Rapid self-assembly of complex biomolecular architectures during mussel byssus biofabrication.Nature communications · 2017Article
- Recent approaches in designing bioadhesive materials inspired by mussel adhesive protein.Journal of polymer science. Part A, Polymer chemistry · 2017Review
- Sugary interfaces mitigate contact damage where stiff meets soft.Nature communications · 2016Article
- Recombinant mussel proximal thread matrix protein promotes osteoblast cell adhesion and proliferation.BMC biotechnology · 2016Article
- Mussel-Inspired Adhesives and Coatings.Annual review of materials research · 2011Article
- Secretion of byssal threads in Mytilus galloprovincialis: quantitative and qualitative values after spawning stress.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2010Article
- Hyperunstable matrix proteins in the byssus of Mytilus galloprovincialis.The Journal of experimental biology · 2009Article
- Bioinspired gradient materials via blending of polymer electrolytes and applying electric forces.The journal of physical chemistry. B · 2009Article
- XSTREAM: a practical algorithm for identification and architecture modeling of tandem repeats in protein sequences.BMC bioinformatics · 2007Article
- Exploring molecular and mechanical gradients in structural bioscaffolds.Biochemistry · 2004Article
- Oxidative stress and the mechanical properties of naturally occurring chimeric collagen-containing fibers.Biophysical journal · 2001Article
- Understanding marine mussel adhesion.Marine biotechnology (New York, N.Y.)Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mussel byssal threads contain unusual block copolymer-like proteins that combine collagen with flanking domains that resemble silk-fibroin (preCol-D) or elastin (preCol-P). These are distributed in complementary gradients along the length of the threads and as precursors in the mussel foot. We discuss a 76-kDa precursor, preCol-NG, from a cDNA library of the foot where it has no gradient but rather is distributed evenly along the distal to proximal axis. A pepsin-resistant fragment of preCol-NG has been confirmed in byssal threads. Like preCol-D and -P, this protein has a central collagenous domain, flanking domains, an acidic patch, and histidine-rich termini. The flanking domains of preCol-NG resemble the glycine-rich proteins of plant cell walls with tandem XGlyn repeats where X denotes alanine, leucine, or asparagine but not proline. Similarity with the (glycine-alanine) repeats and poly(alanine) runs of arthropod silks also exists. Based on available evidence, a model of preCol axial assembly is proposed in which preCol-NG functions as a mediator between preCol-D/-P molecules. This is consistent with the observed progression of mechanical properties in byssal threads.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.