ArticleThe EMBO journal1998
Binding of trithorax and Polycomb proteins to the bithorax complex: dynamic changes during early Drosophila embryogenesis.
Article in The EMBO journal, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
63 citing papers in PubMed, 180 citations in OpenAlex.
- Boundaries potentiate polycomb response element-mediated silencing.BMC biology · 2021Article
- The roles of Polycomb repressive complexes in mammalian development and cancer.Nature reviews. Molecular cell biology · 2021Review
- A theoretical model of Polycomb/Trithorax action unites stable epigenetic memory and dynamic regulation.Nature communications · 2020Article
- Epigenome-wide DNA methylation profiling of preeclamptic placenta according to severe features.Clinical epigenetics · 2020Article
- Serpent/dGATAb regulates Laminin B1 and Laminin B2 expression during Drosophila embryogenesis.Scientific reports · 2019Article
- Three classes of response elements for human PRC2 and MLL1/2-Trithorax complexes.Nucleic acids research · 2018Article
- Dual functionality ofGenes & development · 2017Article
- Review
- Maintenance of Tissue Pluripotency by Epigenetic Factors Acting at Multiple Levels.PLoS genetics · 2016Article
- Chromatin analyses of Zymoseptoria tritici: Methods for chromatin immunoprecipitation followed by high-throughput sequencing (ChIP-seq).Fungal genetics and biology : FG & B · 2015Article
- A variably occupied CTCF binding site in the ultrabithorax gene in the Drosophila bithorax complex.Molecular and cellular biology · 2015Article
- Epigenetics as an answer to Darwin's "special difficulty," Part 2: natural selection of metastable epialleles in honeybee castes.Frontiers in genetics · 2015Review
- A strand-specific switch in noncoding transcription switches the function of a Polycomb/Trithorax response element.Nature genetics · 2014Article
- Quantitative in vivo analysis of chromatin binding of Polycomb and Trithorax group proteins reveals retention of ASH1 on mitotic chromatin.Nucleic acids research · 2013Article
- Identification and Validation of a Putative Polycomb Responsive Element in the Human Genome.PloS one · 2013Article
- Concerted epigenetic signatures inheritance at PcG targets through replication.Cell cycle (Georgetown, Tex.) · 2012Article
- The little elongation complex regulates small nuclear RNA transcription.Molecular cell · 2011Article
- Regulatory mechanisms of tumor suppressor P16(INK4A) and their relevance to cancer.Biochemistry · 2011Review
- Alternative epigenetic chromatin states of polycomb target genes.PLoS genetics · 2010Article
- Structure of the MLL CXXC domain-DNA complex and its functional role in MLL-AF9 leukemia.Nature structural & molecular biology · 2010Article
3 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In Drosophila, the maintenance of developmentally important transcription patterns is controlled at the level of chromatin structure. The Polycomb group (PcG) and trithorax group (trxG) genes encode proteins involved in chromatin remodelling. PcG genes have been proposed to act by packaging transcriptional repressed chromosomal domains into condensed heterochromatin-like structures. Some of the trxG proteins characterized so far are members of chromatin opening complexes (e.g. SWI/SNF and GAGA/NURF) which facilitate binding of transcription factors and components of the basal transcriptional machinery. Genetic and biochemical data suggest that these two groups of regulatory factors may act through a common set of DNA elements. In the present study, we have investigated the binding of Trithorax (TRX) and Polycomb (PC) protein in the bithorax complex (BX-C) during embryogenesis. In addition, we have identified the minimal fragments from the Ultrabithorax (Ubx) regulatory region that are capable of recruiting TRX to chromosomal sites containing them. Comparative analysis of the binding of the two proteins shows that TRX and PC bind target sequences (PcG-regulated elements, PREs) by cellular blastoderm, when BX-C transcription begins. At the same stage, TRX but not PC is strongly associated with core promoters. Later, at germ band extension, the time of derepression in Polycomb mutants, PC binding is also detected outside core PREs and additionally binds to the fragments containing promoters.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.