ArticleThe EMBO journal1998
Transcription through a simple DNA repeat blocks replication elongation.
Article in The EMBO journal, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
45 citing papers in PubMed.
- Triplex H-DNA structure: the long and winding road from the discovery to its role in human disease.NAR molecular medicine · 2024Article
- Article
- Topology and kinetics of R-loop formation.Biophysical journal · 2022Article
- Evolutionary advantage of anti-parallel strand orientation of duplex DNA.Scientific reports · 2020Article
- Structures and stability of simple DNA repeats from bacteria.The Biochemical journal · 2020Review
- Replication of G Quadruplex DNA.Genes · 2019Review
- R-loop generation during transcription: Formation, processing and cellular outcomes.DNA repair · 2018Review
- Mutation at a distance caused by homopolymeric guanine repeats in Saccharomyces cerevisiae.Science advances · 2016Article
- PNA binding to the non-template DNA strand interferes with transcription, suggesting a blockage mechanism mediated by R-loop formation.Molecular carcinogenesis · 2015Article
- The hidden side of unstable DNA repeats: Mutagenesis at a distance.DNA repair · 2015Review
- Strong spurious transcription likely contributes to DNA insert bias in typical metagenomic clone libraries.Microbiome · 2015Article
- Topoisomerase I plays a critical role in suppressing genome instability at a highly transcribed G-quadruplex-forming sequence.PLoS genetics · 2014Article
- Transcription and recombination: when RNA meets DNA.Cold Spring Harbor perspectives in biology · 2014Review
- RNA polymerase between lesion bypass and DNA repair.Cellular and molecular life sciences : CMLS · 2013Review
- Inhibition of DNA synthesis facilitates expansion of low-complexity repeats: is strand slippage stimulated by transient local depletion of specific dNTPs?BioEssays : news and reviews in molecular, cellular and developmental biology · 2013Article
- Transcription blockage by homopurine DNA sequences: role of sequence composition and single-strand breaks.Nucleic acids research · 2013Article
- Modeling translocation dynamics of strand displacement DNA synthesis by DNA polymerase I.Journal of molecular modeling · 2012Article
- Polymerase trafficking: A role for transcription factors in preventing replication fork arrest.Transcription · 2010Article
- Mechanisms and implications of transcription blockage by guanine-rich DNA sequences.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Mutational dynamics of microsatellites.Molecular biotechnology · 2010Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
The influence of d(G)n.d(C)n repeats on plasmid replication in Escherichia coli cells was analyzed using electrophoretic analysis of replication intermediates. These repeats impeded the replication fork in a length- and orientation-dependent manner. Unexpectedly, the replication arrest relied primarily on the repeats' transcription. When the d(C)n sequence served as the transcriptional template, both transcription and replication were blocked. This was true for transcription driven by either bacterial or phage RNA polymerases. We hypothesize that the replication fork halts after it encounters a stalled ternary complex of the RNA polymerase, the DNA template and the r(G)n transcript. This constitutes a novel mechanism for the regulation of replication elongation. The effects of this mechanism on repeat length polymorphism and genome rearrangements are discussed.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.