ReviewDigestive diseases and sciences1998
Nitric oxide as a modulator of intestinal water and electrolyte transport.
Review in Digestive diseases and sciences, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 138 citations in OpenAlex.
- Long-term treatment with mesalazine in patients with symptomatic uncomplicated diverticular disease.Internal and emergency medicine · 2012Trial
- Efficacy of mesalazine in the treatment of symptomatic diverticular disease.Digestive diseases and sciences · 2005Trial
- The impact of l-arginine supplementation on the enteral phase of experimentalJournal of parasitic diseases : official organ of the Indian Society for Parasitology · 2020Article
- Mycotoxins and the Enteric Nervous System.Toxins · 2020Review
- Direct and specific inhibition of constitutive nitric oxide synthase uniquely regulates brush border membrane Na-absorptive pathways in intestinal epithelial cells.Nitric oxide : biology and chemistry · 2018Article
- Magnolol and Honokiol Attenuate Apoptosis of Enterotoxigenic Escherichia Coli-Induced Intestinal Epithelium by Maintaining Secretion and Absorption Homeostasis and Protecting Mucosal Integrity.Medical science monitor : international medical journal of experimental and clinical research · 2018Article
- Pathophysiological mechanisms of diarrhea caused by the Vibrio cholerae O1 El Tor variant: an in vivo study in mice.Virulence · 2016Article
- Inhibiting Inducible Nitric Oxide Synthase in Enteric Glia Restores Electrogenic Ion Transport in Mice With Colitis.Gastroenterology · 2015Article
- Antidiarrhoeal Activity of Musa paradisiaca Sap in Wistar Rats.Evidence-based complementary and alternative medicine : eCAM · 2015Article
- Antidiarrheal mechanism and ionic profile of Carpolobia lutea ethanolic stem-bark extract in rats.African journal of traditional, complementary, and alternative medicines : AJTCAM · 2014Article
- Effects of the viability of Lactobacillus rhamnosus GG on rotavirus infection in neonatal rats.World journal of gastroenterology · 2012Article
- Gasotransmitters: novel regulators of epithelial na(+) transport?Frontiers in physiology · 2012Article
- Nitric oxide regulation of colonic epithelial ion transport: a novel role for enteric glia in the myenteric plexus.The Journal of physiology · 2011Article
- Ion channels in inflammation.Pflugers Archiv : European journal of physiology · 2011Review
- Spasmolytic effect of stachys lavandulifolia vahl. Crude methanolic extract and fractions on rat ileum.Iranian journal of pharmaceutical research : IJPR · 2011Article
- Oral delivery of L-arginine stimulates prostaglandin-dependent secretory diarrhea in Cryptosporidium parvum-infected neonatal piglets.Journal of pediatric gastroenterology and nutrition · 2008Article
- Growth hormone regulates intestinal ion transport through a modulation of the constitutive nitric oxide synthase-nitric oxide-cAMP pathway.World journal of gastroenterology · 2006Article
- Saccharomyces boulardii inhibits water and electrolytes changes induced by castor oil in the rat colon.Digestive diseases and sciences · 2005Article
- Candesartan improves survival following severe hypovolemia in pigs; a role for the angiotensin II type 2 receptor?Intensive care medicine · 2005Article
- A nitrergic secretomotor neurotransmitter in the chloride secretory response to serotonin.Digestive diseases and sciences · 2004Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The role of nitric oxide in intestinal fluid and electrolyte secretion depends upon whether the conditions under study are physiological or pathophysiological. In physiological conditions, endogenous nitric oxide seems to be a proabsorptive molecule, based on the findings that nitric oxide synthase inhibitors reverse net fluid absorption to net secretion in mice, rats, guinea pigs, rabbits, and dogs. This proabsorptive mode involves the enteric nervous system, the suppression of prostaglandin formation, and the opening of basolateral K+ channels. However, in some pathophysiological states nitric oxide synthase may be produced at higher concentrations that are capable of evoking net secretion. Thus nitric oxide synthase contributes to the diarrheal response in trinitrobenzene sulfonic acid-induced ileitis in guinea pigs and is the mediator of the laxative action of several intestinal secretagogues including castor oil, phenolphthalein, bisacodyl, magnesium sulfate, bile salts, senna, and cascara in the rat. Corresponding with the in vivo results, nitric oxide-donating compounds or nitric oxide itself stimulate chloride secretion in the guinea pig and rat intestine in vitro. Exceptions are the diarrhea produced by bacterial enterotoxins in the rat, in which nitric oxide seems to have a proabsorptive role, and the mouse ileum in vitro, in which nitric oxide-donating compounds produce a net proabsorptive effect on basal ion transport. Several endogenous secretagogues (substance P, 5-hydroxytryptamine, interleukin-1beta), which are important mediators of the inflammatory bowel diseases, act, at least in part, through the liberation of nitric oxide. Clinical studies have shown that nitric oxide is elevated in several inflammatory bowel diseases and other secretory conditions including ulcerative colitis, Crohn's disease, toxic megacolon, diverticulitis, infectious gastroenteritis, and infantile methemoglobinemia. However, the determination of nitric oxide in secretory diarrhea per se does not give conclusive information on the nitric oxide contribution to clinical secretory diarrhea.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.