ArticleJournal of anatomy1998
The effects of age on the overall population and on sub-populations of myenteric neurons in the rat small intestine.
Article in Journal of anatomy, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 102 citations in OpenAlex.
- Somatostatin in Aging: Correlations with Selected Central Nervous System and Gastrointestinal Tract Diseases.International journal of molecular sciences · 2026Review
- Mechanisms of enteric neuropathy in diverse contexts of gastrointestinal dysfunction.Neurogastroenterology and motility · 2025Review
- The Aging Enteric Nervous System.International journal of molecular sciences · 2023Review
- Article
- Heparin-binding EGF-like growth factor promotes neuronal nitric oxide synthase expression and protects the enteric nervous system after necrotizing enterocolitis.Pediatric research · 2017Article
- Article
- Aqueous Extract of Agaricus blazei Murrill Prevents Age-Related Changes in the Myenteric Plexus of the Jejunum in Rats.Evidence-based complementary and alternative medicine : eCAM · 2015Article
- Aging of the mammalian gastrointestinal tract: a complex organ system.Age (Dordrecht, Netherlands) · 2014Review
- Alpha-synuclein expression patterns in the colonic submucosal plexus of the aging Fischer 344 rat: implications for biopsies in aging and neurodegenerative disorders?Neurogastroenterology and motility · 2013Article
- Chromatographic analysis of age-related changes in mucosal serotonin transmission in the murine distal ileum.Chemistry Central journal · 2012Article
- Enteric nervous system in the small intestine: pathophysiology and clinical implications.Current gastroenterology reports · 2010Article
- Age-related changes in functional NANC innervation with VIP and substance P in the jejunum of Lewis rats.Autonomic neuroscience : basic & clinical · 2009Article
- 5-HT4 receptor-mediated neuroprotection and neurogenesis in the enteric nervous system of adult mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- Effect of age on the enteric nervous system of the human colon.Neurogastroenterology and motility · 2009Article
- Effects of insulin treatment on HuC/HuD, NADH diaphorase, and nNOS-positive myoenteric neurons of the duodenum of adult rats with acute diabetes.Digestive diseases and sciences · 2009Article
- Ginkgo biloba (EGb 761) extract: effects on the myenteric plexus of the large intestine in Wistar rats.Digestive diseases and sciences · 2009Article
- Effect of chronic, extrinsic denervation on functional NANC innervation with vasoactive intestinal polypeptide and substance P in longitudinal muscle of rat jejunum.Neurogastroenterology and motility · 2008Article
- Innervation of the gastrointestinal tract: patterns of aging.Autonomic neuroscience : basic & clinical · 2007Review
- Long-term effects of extrinsic denervation on VIP and substance P innervation in circular muscle of rat jejunum.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2007Article
- Evaluation of the effect of Ginkgo biloba extract (EGb 761) on the myenteric plexus of the small intestine of Wistar rats.Journal of gastroenterology · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Previous studies on ageing animal and human subjects have demonstrated a significant overall decline in neuronal numbers in the myenteric plexus of the enteric nervous system (ENS). Our study aimed to confirm this observation by counting myenteric neurons stained with the panneuronal markers PGP 9.5 and NADH-diaphorase. We also wished to examine the possibility that particular subpopulations of neurons are vulnerable. Therefore, we have immunostained and counted a number of nerve cell groups within the myenteric plexus of old and young Sprague Dawley rats using markers which reflect some of the neuronal phenotypes present, including ChAT and VIP. The number of neurons demonstrating NADH-diaphorase activity was significantly reduced (P < 0.05) by approximately 15 % in old rats. However, the number of neurons stained for PGP 9.5 immunohistochemistry was not reduced and demonstrated larger numbers of neurons than the NADH-diaphorase method. None of the other neuronal markers studied showed any significant reductions with age. In contrast to previous work, this study has gathered little evidence for extensive cell loss in the myenteric plexus of the aged rat, either in overall populations, or in any of the principal functional groups of neurons.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.