ArticleNucleic acids research1998
The fission yeast chromo domain encoding gene chp1(+) is required for chromosome segregation and shows a genetic interaction with alpha-tubulin.
Article in Nucleic acids research, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 40 citations in OpenAlex.
- Facultative heterochromatin formation in rDNA is essential for cell survival during nutritional starvation.Nucleic acids research · 2022Article
- Review
- An Ancient Yeast for Young Geneticists: A Primer on the Schizosaccharomyces pombe Model System.Genetics · 2015Review
- Replication fork stability is essential for the maintenance of centromere integrity in the absence of heterochromatin.Cell reports · 2013Article
- RNA and epigenetic silencing: insight from fission yeast.Development, growth & differentiation · 2012Review
- The Chp1-Tas3 core is a multifunctional platform critical for gene silencing by RITS.Nature structural & molecular biology · 2011Article
- Article
- Heterochromatin assembly: a new twist on an old model.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2006Review
- Centromere positioning and dynamics in living Arabidopsis plants.Molecular biology of the cell · 2005Article
- RNA interference (RNAi)-dependent and RNAi-independent association of the Chp1 chromodomain protein with distinct heterochromatic loci in fission yeast.Molecular and cellular biology · 2005Article
- A chromodomain protein, Chp1, is required for the establishment of heterochromatin in fission yeast.The EMBO journal · 2004Article
- RNAi-mediated targeting of heterochromatin by the RITS complex.Science (New York, N.Y.) · 2004Article
- Chromatin proteins are determinants of centromere function.Current topics in microbiology and immunology · 2003Review
- Transcriptional silencing in Saccharomyces cerevisiae and Schizosaccharomyces pombe.Nucleic acids research · 2002Review
- The domain structure of centromeres is conserved from fission yeast to humans.Molecular biology of the cell · 2001Article
- Functional redundancies, distinct localizations and interactions among three fission yeast homologs of centromere protein-B.Genetics · 2001Article
- Conservation of heterochromatin protein 1 function.Molecular and cellular biology · 2000Article
- Four chromo-domain proteins of Schizosaccharomyces pombe differentially repress transcription at various chromosomal locations.Genetics · 2000Article
- Fission yeast hrp1, a chromodomain ATPase, is required for proper chromosome segregation and its overexpression interferes with chromatin condensation.Nucleic acids research · 2000Article
- Distinct protein interaction domains and protein spreading in a complex centromere.Genes & development · 2000Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
In eukaryotes, the segregation of chromosomes is co-ordinated by the centromere and must proceed accurately if aneuploidy and cell death are to be avoided. The fission yeast centromere is complex, containing highly repetitive regions of DNA showing the characteristics of heterochromatin. Two proteins, Swi6p and Clr4p, that are associated with the fission yeast centromere also contain a chromo (chromatin organisation modifier) domain and are required for centromere function. We have analysed a novel fission yeast gene encoding a putative chromo domain called chp 1(+) (chromo domain protein in Schizosaccharomyces p ombe ). In the absence of Chp1p protein, cells are viable but show chromosome segregation defects such as lagging chromosomes on the spindle during anaphase and high rates of minichromosome loss, phenotypes which are also displayed by swi 6 and clr 4. A fusion protein between green fluorescent protein (GFP) and Chp1p, like Swi6p, is localized to discrete sites within the nucleus. In contrast to Swi6p and Clr4p, Chp1p is not required to repress silent mating-type genes. We demonstrate a genetic interaction between chp 1(+) and alpha-tubulin ( nda 2(+)) and between swi 6(+) and beta-tubulin ( nda 3(+)). Chp1p and Swi6p proteins may be components of the kinetochore which captures and stabilizes the microtubules of the spindle.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.