ArticleNucleic acids research1998
The MHC class II transactivator (CIITA) requires conserved leucine charged domains for interactions with the conserved W box promoter element.
Article in Nucleic acids research, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
12 citing papers in PubMed, 44 citations in OpenAlex.
- Genome-wide CIITA-binding profile identifies sequence preferences that dictate function versus recruitment.Nucleic acids research · 2015Article
- Molecular characterization of chicken class II transactivator gene.Immunogenetics · 2015Article
- Multiple histone methyl and acetyltransferase complex components bind the HLA-DRA gene.PloS one · 2012Article
- Article
- Mitogen-activated protein kinase ERK1/2 regulates the class II transactivator.The Journal of biological chemistry · 2008Article
- ZXDC, a novel zinc finger protein that binds CIITA and activates MHC gene transcription.Molecular immunology · 2007Article
- Novel mechanisms of class II major histocompatibility complex gene regulation.Immunologic research · 2003Review
- Function and regulation of class II transactivator in the immune system.Immunologic research · 2002Review
- Self-association of CIITA and its transactivation potential.Molecular and cellular biology · 2001Article
- Associations and interactions between bare lymphocyte syndrome factors.Molecular and cellular biology · 2000Article
- Class II transactivator: mastering the art of major histocompatibility complex expression.Molecular and cellular biology · 2000Review
- CIITA is a transcriptional coactivator that is recruited to MHC class II promoters by multiple synergistic interactions with an enhanceosome complex.Genes & development · 2000Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The class II transactivator CIITA is required for transcriptional activation of the major histocompatibility complex (MHC) class II genes. Aside from an N-terminal acidic transcriptional activation domain, little is known about how this factor functions. Extensive mutagenesis of CIITA was undertaken to identify structural motifs required for function. The ability of mutants to activate a reporter gene under the control of MHC class II conserved W-X-Y or X-Y regulatory elements was determined. Two mutants displayed differential activity between the two promoters, activating transcription with the W-X-Y but not the X-Y elements. All mutants were tested for their ability to interfere with wild-type CIITA activity. Five CIITA mutant constructions were able to down-regulate wild-type CIITA activity. Three of these mutants contained targeted disruptions of potential functional motifs: the acidic activation domain, a putative GTP-binding motif and two leucine charged domains (LCD motifs). The other two contained mutations in regions that do not have homology to described proteins. The characterization of CIITA mutants that are able to discriminate between promoters with or without the W box strongly suggests that CIITA requires such interactions for function. The identification of LCD motifs required for CIITA function brings to light a previously undefined role of these motifs in CIITA function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.